Results 261 to 270 of about 47,098 (282)

G-quadruplexes as a source of vulnerability in BRCA2<i>-</i>deficient granule cell progenitors and medulloblastoma. [PDF]

Proc Natl Acad Sci U S A
Keahi DL, Sanders MA, Paul MR, Webster ALH, Fang Y, Wiley TF, Shalaby S, Carroll TS, Chandrasekharappa SC, Sandoval-Garcia C, MacMillan ML, Wagner JE, Hatten ME, Smogorzewska A.   +13 more
europepmc   +1 more source

Molecular basis for RNA discrimination by human DNA ligase 1. [PDF]

Nucleic Acids Res
Tumbale PP, Jurkiw TJ, Krahn JM, Bokil NV, Admiraal SJ, Pedersen LC, Williams JS, Kunkel TA, O'Brien PJ, Williams RS.   +9 more
europepmc   +1 more source

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The DNA-directed RNA polymerases of soybean

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract Four cellular RNA polymerases have been partially purified from hypocotyls of soybean ( Glycine max ). Enzyme isolation from nuclear preparations indicate the DEAE polymerases I and II are localized within the nucleus. Inhibitor studies showed that DEAE polymerase II was preferentially inhibited by α-amanitin, DEAE peaks III and IV were ...
Joe L. Key, Paul A. Horgen
openaire   +4 more sources

Effect of granaticin on the activity of DNA-directed RNA polymerase fromStreptomyces granaticolor

Folia Microbiologica, 1989
DNA-directed RNA polymerase was isolated from wild-type and mutant (asporogenic and granaticin overproducing) Streptomyces granaticolor. The effect of granaticin on the enzyme activity was compared with that of standard transcription inhibitors, rifampicin and rifamycin SV and shown to be zero.
Spízek J, M. Klégr, J. Šmardová, J Stastná   +3 more
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DNA-directed RNA polymerase from HeLa cells

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
Abstract DNA-directed RNA polymerase was solubilized from total HeLa cells. Three distinct classes of the enzyme could be clearly differentiated by their sensitivity toward α-amanitin. While form A is completely resistant to high concentrations (133 μg/ml) of this toxin, enzyme B is highly sensitive and is completely inhibited by concentrations of 0 ...
Bernd J. Benecke, Klaus H. Seifart
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The isolation and properties of a DNA-directed RNA polymerase from yeast mitochondria

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
A method is described for the rapid isolation of yeast mitochondrial DNA-directed RNA polymerase. The enzyme obtained had a specific activity of 1.56 nmol UMP incorporated per mg protein in 20 min at 37 degrees C, and is some 95% pure. This purified enzyme upon polyacrylamide gel elctrophoresis consists of a single polypeptide of 68 000 mol.
openaire   +3 more sources

Improved prediction of prognosis and therapy response for lung adenocarcinoma after identification of DNA-directed RNA polymerase-associated lncRNAs

Journal of Cancer Research and Clinical Oncology, 2023
DNA-directed RNA polymerase (DDRP) related genes and long non-coding RNAs (lncRNAs) play an important role in the development of lung adenocarcinoma (LUAD), the leading cause of cancer-related death worldwide. Therefore, we aimed to construct a DDRP-associated lncRNA model to predict the prognosis of LUAD and to evaluate its sensitivity to ...
Jiaao, Yu, Liqiang, Lan, Caixin, Liu, Xiao, Zhu   +3 more
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Mitochondrial DNA-directed RNA polymerase from Saccharomyces cerevisae mitochondria

Biochemical and Biophysical Research Communications, 1971
Abstract A DNA-directed RNA polymerase activity has been detected in yeast mitochondrial extracts which is sensitive to rifampicin. This activity is distinct from that found in the nucleus and cytoplasm, and is possibly coded for, or under the control of the mitochondrial genome.
openaire   +3 more sources