PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts [PDF]
Nature Communications, 2020 Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
Ann Liza Piberger +10 more
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Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy [PDF]
Molecular Therapy: Oncolytics, 2023 DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The establishment of predictive biomarkers to identify patients who will effectively respond to treatment would allow for the development of personalized therapies. As the
Valeria Guidolin +6 more
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Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts [PDF]
Toxics, 2022 Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
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Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke
Toxics, 2019 DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers.
Bin Ma +2 more
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nLossFinder—A Graphical User Interface Program for the Nontargeted Detection of DNA Adducts [PDF]
Toxics, 2021 DNA adductomics is a relatively new omics approach aiming to measure known and unknown DNA modifications, called DNA adducts. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) has become the most common method for analyzing DNA adducts.
Pedro F. M. Sousa +4 more
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Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. [PDF]
PLoS ONE, 2010 BACKGROUND: Nucleotide excision repair (NER) and base excision repair (BER) are the primary mechanisms for repair of bulky adducts caused by chemical agents, such as PAHs.
Guixiang Ji +8 more
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Biomedical and Pharmacology Journal, 2015 In molecular genetics, a DNA adduct is a piece of DNA covalently bonded to a (cancercausing) chemical. This process could be the start of a cancerous cell, or carcinogenesis.
J Parthiban +4 more
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Redox Biology, 2014 Exocyclic etheno-DNA adducts are mutagenic and carcinogenic and are formed by the reaction of lipidperoxidation (LPO) products such as 4-hydoxynonenal or malondialdehyde with DNA bases.
Kirsten Linhart +2 more
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Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors [PDF]
Genes and Environment, 2021 Background A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings.
Ippei Ohnishi +15 more
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Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides [PDF]
Genes and Environment, 2021 Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guanosine led to ...
F. Peter Guengerich, Pratibha P. Ghodke
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