Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts [PDF]
Toxics, 2022 Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
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Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy [PDF]
Molecular Therapy: Oncolytics, 2023 DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The establishment of predictive biomarkers to identify patients who will effectively respond to treatment would allow for the development of personalized therapies. As the
Valeria Guidolin +6 more
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nLossFinder—A Graphical User Interface Program for the Nontargeted Detection of DNA Adducts [PDF]
Toxics, 2021 DNA adductomics is a relatively new omics approach aiming to measure known and unknown DNA modifications, called DNA adducts. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) has become the most common method for analyzing DNA adducts.
Pedro F. M. Sousa +4 more
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Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors [PDF]
Genes and Environment, 2021 Background A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings.
Ippei Ohnishi +15 more
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Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides [PDF]
Genes and Environment, 2021 Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guanosine led to ...
F. Peter Guengerich, Pratibha P. Ghodke
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Journal of Pharmacy and Bioallied Sciences, 2015 DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.
T R Rajalakshmi +3 more
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Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase [PDF]
PeerJBackground Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer ...
Diana Manapkyzy +8 more
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Toxins, 2022 Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Catalyzed by hepatic cytochrome P450 enzymes, PAs are metabolized into reactive pyrrolic metabolites, which can alkylate ...
Lin Zhu +5 more
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A Comprehensive Database for DNA Adductomics
Frontiers in Chemistry, 2022 The exposure of human DNA to genotoxic compounds induces the formation of covalent DNA adducts, which may contribute to the initiation of carcinogenesis.
Giorgia La Barbera +4 more
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Identification of New Markers of Alcohol-Derived DNA Damage in Humans
Biomolecules, 2021 Alcohol consumption is a risk factor for the development of several cancers, including those of the head and neck and the esophagus. The underlying mechanisms of alcohol-induced carcinogenesis remain unclear; however, at these sites, alcohol-derived ...
Valeria Guidolin +6 more
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