DNA fragment conformations in adducts with Kiteplatin
Dalton Transactions, 2015 The anticancer-active platinum complex with cis-1,4-diaminocyclohexane has proved to be very valuable in detecting multiple conformers in adducts with oligonucleotides.
Emanuele Petruzzella +11 more
openaire +5 more sources
Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics [PDF]
, 2014 Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative ...
Dyson, Paul J. +3 more
core +2 more sources
Biomarker-based evaluation of aflatoxin B1 exposure in cattle [PDF]
Veterinary WorldBackground and Aim: Assessment of aflatoxin B1 (AFB1) exposure in cattle traditionally relies on feed analysis, which may not reflect chronic exposure or accurately indicate individual susceptibility.
Priyadharshini Ponnusamy +8 more
doaj +1 more source
Quantitation of DNA adducts by stable isotope dilution mass spectrometry.
Chemical Research in Toxicology, 2012 Exposure to endogenous and exogenous chemicals can lead to the formation of structurally modified DNA bases (DNA adducts). If not repaired, these nucleobase lesions can cause polymerase errors during DNA replication, leading to heritable mutations and ...
N. Tretyakova +3 more
semanticscholar +1 more source
Benzo[a]pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice [PDF]
, 2014 Background: Gene expression changes induced by carcinogens may identify differences in molecular function between target and non-target organs. Target organs for benzo[a]pyrene (BaP) carcinogenicity in mice (lung, spleen and forestomach) and three non ...
Arlt, Volker M +4 more
core +2 more sources
Molecular Dynamics Studies of Changes in the DNA- Structure as Result of Interactions with Cisplatin [PDF]
arXiv, 2011 The 3'-monofunctional adduct of cisplatin and d(CTCTG*G*TCTC)2 duplex DNA in solvent with explicit counter ions and water molecules were subjected to MD- simulation with AMBER force field on a nanosecond time scale. In order to simulate the closure of the bond between the Pt and 5'-guanine-N7 atoms, the forces acting between them were gradually ...
arxiv
32P-Postlabeling analysis of IQ, MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx- and PhIP-treated monkeys [PDF]
, 1993 The P-32-postlabeling method was used to examine the adducts in DNA, polynucleotides, and mononucleotides reacted in vitro with the N-hydroxy and N-acetoxy derivatives of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3, 8-dimethylimidazo[4,5-f ...
Davis, Cindy D. +4 more
core +1 more source
The speciation of Australopithecus and Paranthropus was caused by introgression from the Gorilla lineage [PDF]
arXiv, 2018 The discovery of Paranthropus deyiremeda in 3.3-3.5 million year old fossil sites in Afar (Haile-Selassie, 2015), together with 30% of the gorilla genome showing lineage sorting between humans and chimpanzees (Scally, 2012), and a NUMT ("nuclear mitochondrial DNA segment") that is shared by both gorillas, humans and chimpanzees, and that dates back to ...
arxiv
Elongation/Compaction of Giant DNA Caused by Depletion Interaction with a Flexible Polymer [PDF]
, 2005 Structural changes in giant DNA induced by the addition of the flexible polymer PEG were examined by the method of single-DNA observation. In dilute DNA conditions, individual DNA assumes a compact state via a discrete coil-globule transition, whereas in concentrated solution, DNA molecules exhibit an extended conformation via macroscopic phase ...
arxiv +1 more source
DNA adducts as a dosimeter for risk estimation.
Environmental Health Perspectives, 1987 The dose response for O6-methylguanine (O6MG) formation and cytotoxicity was determined in lung and nasal mucosa from Fischer 344 rats during multiple dose administration of the tobacco-specific nitrosamine-4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Theodora R. Devereux +3 more
openaire +3 more sources