Results 101 to 110 of about 2,170,594 (309)

Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.

PLoS ONE, 2014
Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage.
Belinda J Nixon, Aimee L Katen, Simone J Stanger, John E Schjenken, Brett Nixon, Shaun D Roman   +5 more
doaj   +1 more source

ERCC1 and ERCC2 haplotype modulates induced BPDE-DNA adducts in primary cultured lymphocytes. [PDF]

PLoS ONE, 2013
BACKGROUND: Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. DNA damage caused by BPDE is normally repaired by Nucleotide Excision Repair (NER), of which ERCC1 and ERCC2/
Xiaobo Lu, Yanhua Liu, Tao Yu, Sha Xiao, Xiaoyan Bao, Liang Pan, Guolian Zhu, Yuan Cai, Qiufang Liu, Cuihong Jin, Jinghua Yang, Shengwen Wu, Li An, Tahar van der Straaten   +13 more
doaj   +1 more source

(15-crown-5)BiI$_3$ as a Building Block for Halogen Bonded Supramolecular Aggregates [PDF]

arXiv, 2020
We present the synthesis and characterization of (15-crown-5)BiI$_3$ (1) and (15-crown-5)BiI$_3$*0.5TIE (2), a halogen bonded adduct with tetraiodoethylene (TIE), a typical halogen bond donor. Our results show that crown ether complexes of main group metal halides can be employed as halogen bond acceptors for the synthesis of new supramolecular ...
arxiv  

Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine.

Chemical Research in Toxicology, 2012
Formaldehyde is a known human and animal carcinogen that forms DNA adducts, and causes mutations. While there is widespread exposure to formaldehyde in the environment, formaldehyde is also an essential biochemical in all living cells.
Kun Lu, Sessaly Craft, Jun Nakamura, B. Moeller, J. Swenberg   +4 more
semanticscholar   +1 more source

Insights into DNA platination within unusual structural settings [PDF]

, 2011
2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie, Parkinson, John A, Wilson, Owen   +2 more
core   +2 more sources

Polycyclic aromatic hydrocarbons and esophageal squamous cell carcinoma [PDF]

, 2012
Esophageal cancer (EC) is the 8th most common cancer and the 6th most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC.
Dawsey, S.M., Malekzadeh, R., Roshandel, G., Semnani, S.   +3 more
core  

Designing organometallic compounds for catalysis and therapy [PDF]

, 2012
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam, Aird, Alama, Alama, Alberto, Allardyce, Allen, Allen, Ana M. Pizarro, Anand, Ang, Ang, Anna Louisa Noffke, Arancibia, Barragan, Barry, Barry, Barry, Barry, Bergamo, Bergamo, Betanzos-Lara, Betanzos-Lara, Betanzos-Lara, Brewster, Bugarcic, Bugarcic, Canivet, Carrión, Caruso, Casini, Casini, Casini, Chaplin, Chen, Chen, del Pozo, Desmard, Dorcier, Dorcier, Dougan, Dougan, Dyson, Erxleben, Feng, Fernandez, Filak, Fu, Fu, Fujii, Giannini, Gormen, Gossens, Grau, Grguric-Sipka, Grubbs, Gröger, Guichard, Guo, Guo, Habtemariam, Hambley, Hamels, Hanif, Hanif, Harris, Hartinger, Hashiguchi, Hayes, Hayward, Herman, Hindi, Hogan, Hollmann, Hu, Hull, Ito, Jafarpour, Jennerwein, Jira, Jungwirth, Kandioller, Kisova, Kljun, Kopf, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kröger, Kuninobu, Lee, Leiva, Li, Liu, Liu, Liu, Liu, Liu, Lo, Lo, Lummen, Lutz, Maenaka, Meggers, Meggers, Meggers, Melchart, Melchart, Melchart, Melendez, Mendes, Motterlini, Mross, Novakova, Novakova, Novakova, Noyori, Noyori, Oehninger, Ogo, Ogo, Olliaro, Page, Patiño, Peacock, Peacock, Peacock, Peacock, Pelletier, Peter J. Sadler, Petzold, Petzold, Pitto-Barry, Pitto-Barry, Pizarro, Plazuk, Rocamora-Reverte, Ruiz, Ruppert, Sandoval, Sanford, Sarsam, Schatzschneider, Schmid, Schäfer, Scolaro, Selander, Skinner, Sriskandakumar, Steckhan, Strohfeldt, Suss-Fink, Sweeney, Takebayashi, Tan, Therrien, Therrien, Toney, Top, Top, Top, Trnka, Turel, van der Donk, van Rijt, van Rijt, van Rijt, Vessières, Vougioukalakis, Vougioukalakis, Wang, Wang, Wang, Ward, Williams, Williams, Wong, Wu, Wu, Yabluchanskiy, Yamakawa, Yan, Yano, Yuasa, Zava, Zekri, Zhao, Zoeller   +188 more
core   +1 more source

Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment.

Toxicological Sciences, 2011
There is a strong need for science-based risk assessment that utilizes known data from diverse sources to arrive at accurate assessments of human health risk. Such assessments will protect the public health without mandating unreasonable regulation. This
J. Swenberg, Kun Lu, B. Moeller, Lina Gao, P. Upton, Jun Nakamura, T. Starr   +6 more
semanticscholar   +1 more source

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core  

Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet [PDF]

, 2011
Peer reviewedPublisher ...
Hani eEl-Nezami, Hani eEl-Nezami, R. John eWallace, Silvia eGratz   +3 more
core   +4 more sources