Results 111 to 120 of about 2,170,594 (309)

Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods.

open access: yesMutagenesis, 2012
Methyleugenol, a secondary metabolite present in many herbal spices, is carcinogenic in various tissues of mice and rats but negative in standard in vitro mutagenicity tests.
K. Herrmann   +4 more
semanticscholar   +1 more source

Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing [PDF]

open access: yes, 2016
Psoralen and ultraviolet A light (PUNTA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft versus-host disease.
Compernolle, Veerle   +7 more
core   +2 more sources

Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde.

open access: yesChemical Research in Toxicology, 2011
In this study, both endogenous and exogenous N(2)-hydroxymethyl-dG adducts in nasal DNA of rats exposed to 0.7, 2, 5.8, 9.1, or 15.2 ppm [(13)CD(2)] formaldehyde for 6 h were quantified by a highly sensitive nano-UPLC-MS/MS method.
Kun Lu   +4 more
semanticscholar   +1 more source

Smoke, alcohol and drug addiction and male fertility [PDF]

open access: yes, 2018
In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates and costs.
DE ANGELIS, Cristina Concetta   +7 more
core   +1 more source

Development of an Optimized Two-Step Solid-Phase Extraction Method for Urinary Nucleic Acid Adductomics

open access: yesBiomolecules
The exposome represents the totality of endogenous and exogenous exposures across the lifespan. These exposures may result in DNA and RNA damage, in the form of adducts, which is a key factor in the etiology of a variety of human diseases, including ...
Alexandra Keidel   +9 more
doaj   +1 more source

Polycyclic Aromatic Hydrocarbons–Aromatic DNA Adducts in Cord Blood and Behavior Scores in New York City Children

open access: yesEnvironmental Health Perspectives, 2011
Background: Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban pollutants that can bind to DNA to form PAH–DNA adducts. Prenatal PAH exposure measured by personal monitoring has been linked to cognitive deficits in childhood in a ...
F. Perera   +7 more
semanticscholar   +1 more source

Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives [PDF]

open access: yes, 2014
Alcohol consumption is associated with an increased risk of breast cancer, increasing linearly even with a moderate consumption and irrespectively of the type of alcoholic beverage.
Castro, Gerardo Daniel   +1 more
core   +1 more source

An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process [PDF]

open access: yes, 2020
Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair.
Cortés Ledesma, Felipe   +2 more
core   +1 more source

Urinary DNA adductomics – A novel approach for exposomics

open access: yesEnvironment International, 2018
The exposome is a concept that encompasses the totality of internal and external environmental exposures, from conception onwards. Evaluation of the exposome, across the lifecourse represents a significant challenge, e.g., methods/technology may simply ...
Marcus S. Cooke   +3 more
doaj  

DNA-based Artificial Nanostructures: Fabrication, Properties, and Applications [PDF]

open access: yesarXiv, 2005
Table of Content 1. Introduction 2. DNA fundamentals 3. Attachment of DNA to surface 4. Fabrication of nanostructures using DNA 4.1 Nanostructures of pure DNA 4.2 DNA-based assembly of metal nanoparticles 4.3 Construction of semiconductor particle arrays using DNA 4.4 DNA-directed nanowires 4.5 DNA-functionalized carbon nanotubes 4 ...
arxiv  

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