Results 111 to 120 of about 55,387 (283)

Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation. [PDF]

J Nanobiotechnology, 2022
Xu L, Zhang K, Ma X, Li Y, Jin Y, Liang C, Wang Y, Duan W, Zhang H, Zhang Z, Shi J, Liu J, Wang Y, Li W.   +13 more
europepmc   +1 more source

Data from Red Wine Consumption is Inversely Associated with 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine–DNA Adduct Levels in Prostate

, 2023
Benjamin A. Rybicki, Christine Neslund‐Dudas, Cathryn H. Bock, Nora L. Nock, Andrew Rundle, Michelle Jankowski, Albert M. Levin, Jennifer Beebe‐Dimmer, Adnan T. Savera, Satoru Takahashi, Tomoyuki Shirai, Deliang Tang   +11 more
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

DNA adducts as link between in vitro and in vivo carcinogenicity - A case study with benzo[a]pyrene. [PDF]

Curr Res Toxicol, 2023
Gerhards M, Böhme A, Schubert K, Kodritsch B, Ulrich N.   +4 more
europepmc   +1 more source

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3‐nitrobenzanthrone in rat lung at the C8 and N² position of guanine and at the N⁶ position of adenine

, 2005
Volker M. Arlt, Heinz H. Schmeiser, Martin R. Osborne, Masanobu Kawanishi, Takaharu Kanno, Takashi Yagi, David H. Phillips, Takeji Takamura‐Enya   +7 more
openalex   +2 more sources

O⁶‐carboxymethylguanine DNA adduct formation and lipid peroxidation upon in vitro gastrointestinal digestion of haem‐rich meat [PDF]

, 2014
Julie Vanden Bussche, Lieselot Hemeryck, Thomas Van Hecke, Gunter Kuhnle, Frank Pasmans, Sharon A. Moore, Tom Van de Wiele, Stefaan De Smet, Lynn Vanhaecke   +8 more
openalex   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Aflatoxin B1 DNA-Adducts in Hepatocellular Carcinoma from a Low Exposure Area. [PDF]

Nutrients, 2022
Gramantieri L, Gnudi F, Vasuri F, Mandrioli D, Fornari F, Tovoli F, Suzzi F, Vornoli A, D'Errico A, Piscaglia F, Giovannini C.   +10 more
europepmc   +1 more source

Identification and Quantification of DNA Adducts in the Oral Tissues of Mice Treated with the Environmental Carcinogen Dibenzo[a,l]pyrene by HPLC-MS/MS

, 2011
Shang-Min Zhang, Kun-Ming Chen, César Aliaga, Yuan‐Wan Sun, Jyh-Ming Lin, Arun Sharma, Shantu Amin, Karam El‐Bayoumy   +7 more
openalex   +2 more sources

Unveiling CLC as a Central Regulator of Allergic Rhinitis via the CLC‐CCL26/POSTN Axis: An Integrated Bioinformatics and Experimental Study

Flavour and Fragrance Journal, EarlyView.
We unveil that CLC orchestrates the dual role of eosinophil recruitment via CCL26 and tissue remodelling via POSTN in allergic rhinitis, identifying it as a potential therapeutic target. ABSTRACT Allergic rhinitis (AR) is a chronic airway inflammation driven by a type 2 immune response, yet the molecular mechanisms underlying its persistence and tissue
Fanyu Yuan, Yuhan Dong, Zishuo Guo, Xiaodong Zhao, Jian Liu, Fangyuan Zhu, Shengjie Ge, Chengcheng Liu, Shuai Xu, Ming Xia   +9 more
wiley   +1 more source