Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer
Breast Cancer: Basic and Clinical Research, 2009 Endogenous estrogens can be bio-activated to endogenous carcinogens via formation of estrogen quinones. Estrogen-3,4-quinones react with DNA to form mutagenic depurinating estrogen-DNA adducts.
Nilesh W. Gaikwad +6 more
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Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. [PDF]
PLoS ONE, 2011 The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on ...
Debadeep Bhattacharyya +10 more
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Interactions of Cisplatin and Daunorubicin at the chromatin level [PDF]
, 2020 Unexpectedly, the widely used anticancer agents Cisplatin (Cis-Pt) and Daunorubicin (Dauno) exhibited cell type- and concentration-dependent synergy or antagonism in vitro.
Bacsó, Zsolt +7 more
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Sperm DNA adducts impair fertilization during ICSI but not during IVF.
Folia Histochemica et Cytobiologica, 2008 Many studies emphasize the influence of the status of spermatozoal nucleus on fertilization, mainly with regard to DNA fragmentation. This study was undertaken to analyze the influence of DNA adducts content in spermatozoa on fertilization during ...
Stanisław HorĂĄk +2 more
doaj +3 more sources
DNA adducts in fish following an oil spill exposure [PDF]
, 2006 On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast.
A. Amat +36 more
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Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation [PDF]
, 1997 Reductive activation of racemic 1,10-bis(acetoxy)-7-methoxymitosene WV15 in the presence of DNA, followed by enzymatic digestion and HPLC analysis, revealed the formation of various DNA adducts.
Duynhoven, John P.M. van +8 more
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Pyrimido[1,2-a]-purin-10(3H)-one, M(1)G, is less prone to artifact than base oxidation [PDF]
, 2005 Pyrimido[1,2-a]-purin-10(3H)-one (M(1)G) is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose.
Jeong, Yo-Chan +3 more
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Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran [PDF]
, 2009 We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world.
Biramijamal, F. +4 more
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BMC Veterinary Research, 2021 Background Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies.
Kristine Walters +9 more
doaj +1 more source
Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]
, 1990 2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M. +5 more
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