PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts [PDF]
Nature Communications, 2020 Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
Ann Liza Piberger +10 more
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Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts [PDF]
Toxics, 2022 Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
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Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy [PDF]
Molecular Therapy: Oncolytics, 2023 DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The establishment of predictive biomarkers to identify patients who will effectively respond to treatment would allow for the development of personalized therapies. As the
Valeria Guidolin +6 more
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nLossFinder—A Graphical User Interface Program for the Nontargeted Detection of DNA Adducts [PDF]
Toxics, 2021 DNA adductomics is a relatively new omics approach aiming to measure known and unknown DNA modifications, called DNA adducts. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) has become the most common method for analyzing DNA adducts.
Pedro F. M. Sousa +4 more
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Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke
Toxics, 2019 DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers.
Bin Ma +2 more
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Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors [PDF]
Genes and Environment, 2021 Background A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings.
Ippei Ohnishi +15 more
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Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides [PDF]
Genes and Environment, 2021 Etheno (and ethano) derivatives of nucleic acid bases have an extra 5-membered ring attached. These were first noted as wyosine bases in tRNAs. Some were fluorescent, and the development of etheno derivatives of adenosine, cytosine, and guanosine led to ...
F. Peter Guengerich, Pratibha P. Ghodke
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Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Journal of Nucleic Acids, 2010 DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
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Differential Toxicity of DNA Adducts of Mitomycin C
Journal of Nucleic Acids, 2010 The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell ...
Jill Bargonetti +2 more
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Toxins, 2022 Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Catalyzed by hepatic cytochrome P450 enzymes, PAs are metabolized into reactive pyrrolic metabolites, which can alkylate ...
Lin Zhu +5 more
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