Results 11 to 20 of about 2,409,493 (295)
Journal of Pharmacy and Bioallied Sciences, 2015 DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication.
T R Rajalakshmi +3 more
doaj +3 more sources
Strain and Sex Variability in Liver, Kidney and Lung Levels of DNA Adducts EB-GII and bis-N7G-BD Following Inhalation Exposure to 1,3-Butadiene in Collaborative Cross Mice [PDF]
Toxics1,3-butadiene (BD) is a volatile organic pollutant. Upon inhalation, it is metabolically activated to reactive epoxides which alkylate genomic DNA and form potentially mutagenic monoadducts and DNA–DNA crosslinks including N7-(1-hydroxyl-3-buten-1-yl ...
Erik Moran +5 more
doaj +2 more sources
Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase [PDF]
PeerJBackground Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer ...
Diana Manapkyzy +8 more
doaj +3 more sources
Toxins, 2022 Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Catalyzed by hepatic cytochrome P450 enzymes, PAs are metabolized into reactive pyrrolic metabolites, which can alkylate ...
Lin Zhu +5 more
doaj +1 more source
A Comprehensive Database for DNA Adductomics
Frontiers in Chemistry, 2022 The exposure of human DNA to genotoxic compounds induces the formation of covalent DNA adducts, which may contribute to the initiation of carcinogenesis.
Giorgia La Barbera +4 more
doaj +1 more source
Identification of New Markers of Alcohol-Derived DNA Damage in Humans
Biomolecules, 2021 Alcohol consumption is a risk factor for the development of several cancers, including those of the head and neck and the esophagus. The underlying mechanisms of alcohol-induced carcinogenesis remain unclear; however, at these sites, alcohol-derived ...
Valeria Guidolin +6 more
doaj +1 more source
Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer
Breast Cancer: Basic and Clinical Research, 2009 Endogenous estrogens can be bio-activated to endogenous carcinogens via formation of estrogen quinones. Estrogen-3,4-quinones react with DNA to form mutagenic depurinating estrogen-DNA adducts.
Nilesh W. Gaikwad +6 more
doaj +2 more sources
Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. [PDF]
PLoS ONE, 2011 The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on ...
Debadeep Bhattacharyya +10 more
doaj +1 more source
Sperm DNA adducts impair fertilization during ICSI but not during IVF.
Folia Histochemica et Cytobiologica, 2008 Many studies emphasize the influence of the status of spermatozoal nucleus on fertilization, mainly with regard to DNA fragmentation. This study was undertaken to analyze the influence of DNA adducts content in spermatozoa on fertilization during ...
Stanisław HorĂĄk +2 more
doaj +3 more sources
BMC Veterinary Research, 2021 Background Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies.
Kristine Walters +9 more
doaj +1 more source