Results 21 to 30 of about 2,409,493 (295)
Mass spectrometry reviews (Print), 2018 Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer.
Byeong Hwa Yun +3 more
semanticscholar +1 more source
Polycyclic aromatic hydrocarbons and PAH-related DNA adducts
Journal of Applied Genetics, 2016 Investigations on the impact of chemicals on the environment and human health have led to the development of an exposome concept. The exposome refers to the totality of exposures received by a person during life, including exposures to life-style factors,
Błaszczyk Ewa +1 more
semanticscholar +1 more source
Targeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage
Frontiers in Chemistry, 2019 DNA can be damaged through covalent modifications of the nucleobases by endogenous processes. These modifications, commonly referred to as DNA adducts, can persist and may lead to mutations, and ultimately to the initiation of cancer.
Andrea Carrà +6 more
doaj +1 more source
MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts
Journal of Cell Biology, 2016 Analyses in Xenopus egg extracts show that the MRN complex, CtIP, BRCA1, and the interaction between CtIP and BRCA1 are required for the removal of Top2–DNA adducts, forsubsequent resection of Top2-adducted double-strand break ends, and for cellular ...
T. Aparicio +3 more
semanticscholar +1 more source
Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]
PLoS ONE, 2015 Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa +4 more
doaj +1 more source
Clinical and Translational Medicine, 2016 Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts.
E. Cavalieri, E. Rogan
semanticscholar +1 more source
Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA
Toxins, 2010 Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jamie E. Jennings-Gee +5 more
doaj +1 more source
Urinary DNA adductomics – A novel approach for exposomics
Environment International, 2018 The exposome is a concept that encompasses the totality of internal and external environmental exposures, from conception onwards. Evaluation of the exposome, across the lifecourse represents a significant challenge, e.g., methods/technology may simply ...
Marcus S. Cooke +3 more
doaj +1 more source
Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency. [PDF]
PLoS ONE, 2016 XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex recognizes DNA adducts to initiate NER. To determine the mutagenic potential of structurally different bulky DNA damages, various studies have been ...
Benjamin Hilton +6 more
doaj +1 more source
The Response of the Replication Apparatus to Leading Template Strand Blocks
Cells, 2023 Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand.
Marina A. Bellani +4 more
doaj +1 more source