Results 21 to 30 of about 55,387 (283)
Urinary DNA adductomics – A novel approach for exposomics
Environment International, 2018 The exposome is a concept that encompasses the totality of internal and external environmental exposures, from conception onwards. Evaluation of the exposome, across the lifecourse represents a significant challenge, e.g., methods/technology may simply ...
Marcus S. Cooke +3 more
doaj +1 more source
Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency. [PDF]
PLoS ONE, 2016 XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex recognizes DNA adducts to initiate NER. To determine the mutagenic potential of structurally different bulky DNA damages, various studies have been ...
Benjamin Hilton +6 more
doaj +1 more source
In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line
Frontiers in Chemistry, 2019 In the development of new chemical substances, genetic toxicity evaluations are a high priority for safety risk management. Evaluation of the possibility of compound carcinogenicity with accuracy and at reasonable cost in the early stages of development ...
Toshihide Takeshita, Robert A. Kanaly
doaj +1 more source
The Response of the Replication Apparatus to Leading Template Strand Blocks
Cells, 2023 Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand.
Marina A. Bellani +4 more
doaj +1 more source
Alcohol, Aldehydes, Adducts and Airways
Biomolecules, 2015 Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA.
Muna Sapkota, Todd A. Wyatt
doaj +1 more source
Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke
Toxics, 2019 DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers.
Bin Ma +2 more
doaj +1 more source
Sperm DNA oxidative damage and DNA adducts [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015 The objective of this study was to investigate DNA damage and adducts in sperm from coke oven workers who have been exposed to polycyclic aromatic hydrocarbons. A longitudinal study was conducted with repeated measurements during spermatogenesis. Coke-oven workers (n=112) from a coke-oven plant served the PAH-exposed group, while administrators and ...
Jeng, Hueiwang Anna +3 more
openaire +3 more sources
Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Journal of Nucleic Acids, 2010 DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
doaj +1 more source
Redox Biology, 2014 Exocyclic etheno-DNA adducts are mutagenic and carcinogenic and are formed by the reaction of lipidperoxidation (LPO) products such as 4-hydoxynonenal or malondialdehyde with DNA bases.
Kirsten Linhart +2 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source