Results 31 to 40 of about 103,979 (334)

The Response of the Replication Apparatus to Leading Template Strand Blocks

Cells, 2023
Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand.
Marina A. Bellani, Althaf Shaik, Ishani Majumdar, Chen Ling, Michael M. Seidman   +4 more
doaj   +1 more source

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]

, 2010
Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Baynes, Boyum, Brigitte M. Winklhofer-Roob, Cao, Cao, Chan, Chung, Cooke, Cooke, De Bont, Dobler, Duewelhenke, Fleming, Frischmann, Gatenby, Hou, Kang, Krymkiewicz, Larisch, Li, Luo, Michael R. Stratton, Morcos, Naila Rabbani, Nicolay, Papoulis, Paul J. Thornalley, Pfaffl, Pischetsrieder, Rock, Sahar Waris, Sakamoto, Sakamoto, Sarah J. Larkin, Schneider, Seidel, Shapiro, Synold, Thomas Fleming, Thomas Santarius, Thornalley, Thornalley, Thornalley, Thornalley, Thornalley, Vaca, Wang, Yeluri, Yuan   +48 more
core   +2 more sources

Protein Adductomics: Methodologies for Untargeted Screening of Adducts to Serum Albumin and Hemoglobin in Human Blood Samples. [PDF]

, 2019
The reaction products of electrophiles in vivo can be measured as adducts to the abundant proteins, hemoglobin (Hb), and human serum albumin (HSA), in human blood samples.
Carlsson, Henrik, Rappaport, Stephen, Törnqvist, Margareta   +2 more
core   +2 more sources

Alcohol, Aldehydes, Adducts and Airways

Biomolecules, 2015
Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA.
Muna Sapkota, Todd A. Wyatt
doaj   +1 more source

Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts [PDF]

, 2013
Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action.
Bancroft, Brabec, Brabec, Brabec, Butler, Caradonna, Coluccia, Dhara, Eastman, Eastman, Farrell, Farrer, Farrer, Fichtinger-Schepman, Guddneppanavar, Hall, Hamers, Harper, Intini, Jamieson, Kasparkova, Kasparkova, Kauffman, Keck, Kelland, Lau, Lemaire, Mackay, Mackay, Mackay, Najajreh, Ohndorf, O’Dwyer, Pantoja, Phillips, Pracharova, Pregosin, Prokop, Reedijk, Ronconi, Salassa, Salassa, Salassa, Salassa, Siddik, Stehlíková, Still, Suchánková, Tai, Vinje, Vlček, Wang, Westendorf, Westendorf, Westendorf, Wong, Yao, Zenker   +57 more
core   +1 more source

In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line

Frontiers in Chemistry, 2019
In the development of new chemical substances, genetic toxicity evaluations are a high priority for safety risk management. Evaluation of the possibility of compound carcinogenicity with accuracy and at reasonable cost in the early stages of development ...
Toshihide Takeshita, Robert A. Kanaly
doaj   +1 more source

The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts. [PDF]

, 2016
Enzymatic approaches for locating alkylation adducts at single-base resolution in DNA could enable new technologies for understanding carcinogenesis and supporting personalized chemotherapy.
Andreas Marx, Arman Nilforoushan, Boosalis, David M. Williams, Laura A. Wyss, Rydberg, Shana J. Sturla   +6 more
core   +2 more sources

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core   +2 more sources

Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke

Toxics, 2019
DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers.
Bin Ma, Irina Stepanov, Stephen S. Hecht   +2 more
doaj   +1 more source

Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

Journal of Nucleic Acids, 2010
DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
doaj   +1 more source