Results 31 to 40 of about 2,170,594 (309)
Mass spectrometry reviews (Print), 2018 Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer.
Byeong Hwa Yun +3 more
semanticscholar +1 more source
BMC Veterinary Research, 2021 Background Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies.
Kristine Walters +9 more
doaj +1 more source
Polycyclic aromatic hydrocarbons and PAH-related DNA adducts
Journal of Applied Genetics, 2016 Investigations on the impact of chemicals on the environment and human health have led to the development of an exposome concept. The exposome refers to the totality of exposures received by a person during life, including exposures to life-style factors,
Błaszczyk Ewa +1 more
semanticscholar +1 more source
MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts
Journal of Cell Biology, 2016 Analyses in Xenopus egg extracts show that the MRN complex, CtIP, BRCA1, and the interaction between CtIP and BRCA1 are required for the removal of Top2–DNA adducts, forsubsequent resection of Top2-adducted double-strand break ends, and for cellular ...
T. Aparicio +3 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2017 Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-
M. Stiborová, V. Arlt, H. Schmeiser
semanticscholar +1 more source
Targeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage
Frontiers in Chemistry, 2019 DNA can be damaged through covalent modifications of the nucleobases by endogenous processes. These modifications, commonly referred to as DNA adducts, can persist and may lead to mutations, and ultimately to the initiation of cancer.
Andrea Carrà +6 more
doaj +1 more source
Chemical Research in Toxicology, 2018 Epidemiological studies have linked aromatic amines (AAs) from tobacco smoke and some occupational exposures with bladder cancer risk. Several epidemiological studies have also reported a plausible role for structurally related heterocyclic aromatic ...
Jingshu Guo +6 more
semanticscholar +1 more source
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]
, 2010 Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Baynes +48 more
core +2 more sources
Clinical and Translational Medicine, 2016 Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts.
E. Cavalieri, E. Rogan
semanticscholar +1 more source
Unusual DNA binding modes for metal anticancer complexes [PDF]
, 2009 DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core +1 more source