Results 31 to 40 of about 2,409,493 (295)
Alcohol, Aldehydes, Adducts and Airways
Biomolecules, 2015 Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA.
Muna Sapkota, Todd A. Wyatt
doaj +1 more source
In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line
Frontiers in Chemistry, 2019 In the development of new chemical substances, genetic toxicity evaluations are a high priority for safety risk management. Evaluation of the possibility of compound carcinogenicity with accuracy and at reasonable cost in the early stages of development ...
Toshihide Takeshita, Robert A. Kanaly
doaj +1 more source
Sperm DNA oxidative damage and DNA adducts [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015 The objective of this study was to investigate DNA damage and adducts in sperm from coke oven workers who have been exposed to polycyclic aromatic hydrocarbons. A longitudinal study was conducted with repeated measurements during spermatogenesis. Coke-oven workers (n=112) from a coke-oven plant served the PAH-exposed group, while administrators and ...
Jeng, Hueiwang Anna +3 more
openaire +3 more sources
Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Journal of Nucleic Acids, 2010 DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
doaj +1 more source
Analytical Chemistry, 2014 Liquid chromatography coupled with mass spectrometry (LC-MS) is the method of choice for analysis of covalent modification of DNA. DNA adductomics is an extension of this approach allowing for the screening for both known and unknown DNA adducts.
S. Balbo +3 more
semanticscholar +1 more source
Simultaneous Detection of Multiple DNA Adducts in Human Lung Samples by Isotope-Dilution UPLC-MS/MS
Analytical Chemistry, 2014 Recent studies have demonstrated that various DNA adducts can be detected in human tissues and fluids using liquid chromatography connected to tandem mass spectrometry (LC-MS/MS).
B. Monien +5 more
semanticscholar +1 more source
Tracing the fates of site-specifically introduced DNA adducts in the human genome.
DNA Repair, 2014 We developed a system for tracing DNA adducts in targeted mutagenesis (TATAM) and investigated the prevalence and types of consequent mutations. Targeted mutagenesis methods site-specifically replace endogenous DNA bases with bases carrying synthetic ...
M. Yasui +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Differential Toxicity of DNA Adducts of Mitomycin C
Journal of Nucleic Acids, 2010 The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell ...
Jill Bargonetti +2 more
doaj +1 more source
Toxics, 2018 The measurement of DNA adducts provides important information about human exposure to genotoxic chemicals and can be employed to elucidate mechanisms of DNA damage and repair.
Byeong Hwa Yun +2 more
doaj +1 more source