Results 41 to 50 of about 2,170,594 (309)
Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]
PLoS ONE, 2015 Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa +4 more
doaj +1 more source
Base-Resolution Analysis of Cisplatin-DNA Adducts at the Genome Scale.
Angewandte Chemie, 2016 Cisplatin, one of the most widely used anticancer drugs, crosslinks DNA and ultimately induces cell death. However, the genomic pattern of cisplatin-DNA adducts has remained unknown owing to the lack of a reliable and sensitive genome-wide method. Herein
Xiaoting Shu +4 more
semanticscholar +1 more source
Sperm DNA oxidative damage and DNA adducts [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015 The objective of this study was to investigate DNA damage and adducts in sperm from coke oven workers who have been exposed to polycyclic aromatic hydrocarbons. A longitudinal study was conducted with repeated measurements during spermatogenesis. Coke-oven workers (n=112) from a coke-oven plant served the PAH-exposed group, while administrators and ...
Jeng, Hueiwang Anna +3 more
openaire +4 more sources
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]
, 2012 Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Austin, Caroline +10 more
core +3 more sources
Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA
Toxins, 2010 Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jamie E. Jennings-Gee +5 more
doaj +1 more source
Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency. [PDF]
PLoS ONE, 2016 XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex recognizes DNA adducts to initiate NER. To determine the mutagenic potential of structurally different bulky DNA damages, various studies have been ...
Benjamin Hilton +6 more
doaj +1 more source
IMG-DNA: Approximate DNA Storage for Images [PDF]
, 2021 Deoxyribonucleic Acid (DNA) as a storage medium with high density and long-term preservation properties can satisfy the requirement of archival storage for rapidly increased digital volume. The read and write processes of DNA storage are error-prone. Images widely used in social media have the properties of fault tolerance which are well fitted to the ...
arxiv +1 more source
Synthesis, reactivity studies, and cytotoxicity of two trans-Iodidoplatinum(II) complexes. Does photoactivation work? [PDF]
, 2018 trans-Platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin.
Carnero Moya, Amancio +5 more
core +1 more source
The Response of the Replication Apparatus to Leading Template Strand Blocks
Cells, 2023 Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand.
Marina A. Bellani +4 more
doaj +1 more source
Analytical Chemistry, 2016 Epidemiologic studies have reported an association between frequent consumption of well-done cooked meats and prostate cancer risk. However, unambiguous physiochemical markers of DNA damage from carcinogens derived from cooked meats, such as DNA adducts,
S. Xiao +8 more
semanticscholar +1 more source