Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts [PDF]
, 2013 Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action.
Bancroft +57 more
core +1 more source
Alcohol, Aldehydes, Adducts and Airways
Biomolecules, 2015 Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA.
Muna Sapkota, Todd A. Wyatt
doaj +1 more source
Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts.
Chemical Society Reviews, 2015 Exogenous and endogenous sources of chemical species can react, directly or after metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may compromise cellular functions by blocking DNA replication and/or inducing mutations ...
Shuo Liu, Yinsheng Wang
semanticscholar +1 more source
The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts. [PDF]
, 2016 Enzymatic approaches for locating alkylation adducts at single-base resolution in DNA could enable new technologies for understanding carcinogenesis and supporting personalized chemotherapy.
Andreas Marx +6 more
core +2 more sources
A simple theory of molecular organization in fullerene containing liquid crystals [PDF]
J CHEM PHYS 123 (16): art. no. 164904 OCT 22 2005, 2005 Systematic efforts to synthesise fullerene containing LCs have produced a variety of successful model compounds. We present a simple molecular theory relating the self-organisation observed in these systems to their molecular structure. The interactions are modelled by dividing each molecule into a number of sub-molecular blocks to which specific ...
arxiv +1 more source
Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography tandem mass spectrometry. [PDF]
, 2017 RATIONALE: The lipid peroxidation product malondialdehyde forms M1 dG adducts with guanine bases in genomic DNA. The analysis of these adducts is important as a biomarker of lipid peroxidation, oxidative stress and inflammation which may be linked to ...
Dempster, NM +3 more
core +2 more sources
In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line
Frontiers in Chemistry, 2019 In the development of new chemical substances, genetic toxicity evaluations are a high priority for safety risk management. Evaluation of the possibility of compound carcinogenicity with accuracy and at reasonable cost in the early stages of development ...
Toshihide Takeshita, Robert A. Kanaly
doaj +1 more source
Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides [PDF]
, 2010 We show that UVA irradiation (365 nm) of the Pt-IV complex trans,trans,trans-[(PtCl2)-Cl-IV(OH)(2)(dimethylamine) (isopropylamine)] (1), induces reduction to Pt-II photoproducts.
Cubo, Leticia +5 more
core +1 more source
, 2016 In molecular genetics, a DNA adduct is a piece of DNA covalently bonded to a (cancercausing) chemical. This process could be the start of a cancerous cell, or carcinogenesis.
J. Parthiban +4 more
semanticscholar +1 more source
Analytical Chemistry, 2014 Liquid chromatography coupled with mass spectrometry (LC-MS) is the method of choice for analysis of covalent modification of DNA. DNA adductomics is an extension of this approach allowing for the screening for both known and unknown DNA adducts.
S. Balbo +3 more
semanticscholar +1 more source