Results 71 to 80 of about 103,979 (334)

Biomarker-based evaluation of aflatoxin B1 exposure in cattle [PDF]

Veterinary World
Background and Aim: Assessment of aflatoxin B1 (AFB1) exposure in cattle traditionally relies on feed analysis, which may not reflect chronic exposure or accurately indicate individual susceptibility.
Priyadharshini Ponnusamy, Umaya Suganthi Rajendran, Madhavan Gopalakrishnan Nair, Uma Sambath, Raja Kumar, Jacob Thanislass, Avinash Warundeo Lakkawar, Vijayalakshmi Padmanaban, Poobitha Subbarayan   +8 more
doaj   +1 more source

DNA fragment conformations in adducts with Kiteplatin

Dalton Transactions, 2015
The anticancer-active platinum complex with cis-1,4-diaminocyclohexane has proved to be very valuable in detecting multiple conformers in adducts with oligonucleotides.
Emanuele Petruzzella, Patricia A. Marzilli, James D. Hoeschele, James Alexis Platts, Paride Papadia, Luigi G. Marzilli, Shaun T. Mutter, Nicola Margiotta, Giovanni Natile, Robert J. Deeth, Rosa Ranaldo, Rosa Ranaldo   +11 more
openaire   +5 more sources

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics [PDF]

, 2014
Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative ...
Dyson, Paul J., Menin, Laure, Murray, Benjamin S., Scopelliti, Rosario   +3 more
core   +2 more sources

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Advanced Healthcare Materials, EarlyView.
Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti, Claudia Catarinicchia, Claudia Borri, Fulvio Ratto, Filippo Micheletti, Noemi Formica, Jessica Ruzzolini, Elena Frediani, Anastasia Chillà, Francesca Margheri, Mirko Severi, Rita Traversi, Patrizia Nardini, Daniele Guasti, Mario Del Rosso, Tommaso Del Rosso, Lisa Giovanelli, Cinzia Talamonti, Monica Mangoni, Isacco Desideri, Silvia Burchielli, Fabiola Pajar, Gabriella Fibbi, Anna Laurenzana   +26 more
wiley   +1 more source

Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]

, 2009
The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core   +1 more source

Functionalized Antifouling Polymer Brushes for Biospecific Surfaces

Advanced Materials Interfaces, EarlyView.
Modern biosensors offer high sensitivity but often struggle with long‐term stability and selectivity for specific targets. Antifouling polymer brushes help enhance both stability and selectivity. In this review, we compare recent antifouling coatings, their design parameters, and how they are integrated with biorecognition elements for improved ...
Erik J. Postma, Luc Scheres, Sissi de Beer, Andriy R. Kuzmyn, Han Zuilhof   +4 more
wiley   +1 more source

Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet [PDF]

, 2011
Peer reviewedPublisher ...
Hani eEl-Nezami, Hani eEl-Nezami, R. John eWallace, Silvia eGratz   +3 more
core   +4 more sources

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

DNA adducts as a dosimeter for risk estimation.

Environmental Health Perspectives, 1987
The dose response for O6-methylguanine (O6MG) formation and cytotoxicity was determined in lung and nasal mucosa from Fischer 344 rats during multiple dose administration of the tobacco-specific nitrosamine-4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Theodora R. Devereux, Marshall W. Anderson, Catherine M. White, Steven A. Belinsky   +3 more
openaire   +3 more sources

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core