Results 81 to 90 of about 55,387 (283)

A computational study of the structures and base-pairing properties of pyrrolizidine alkaloid-derived DNA adducts

, 2023
Mckenzie Franz, Melanie S. Kebel, Pardeepak S. Sandhu, Denisa Moldovan, Taylor P. K. Adamitz, Rajwinder Kaur, Ye Eun Rebecca Jeong, Stacey D. Wetmore   +7 more
openalex   +1 more source

Dietary curcumin post-treatment enhances the disappearance of B(a)P-derived DNA adducts in mouse liver and lungs

Toxicology Reports, 2014
To study the post-treatment effects of dietary curcumin on the levels of benzo(a)pyrene [B(a)P]-induced DNA adducts, mice were administered oil or B(a)P and randomized into 7 subgroups after 24 h.
Gaurav Kumar, Pooja Tajpara, Amirali B. Bukhari, Asha G. Ramchandani, Abhijit De, Girish B. Maru   +5 more
doaj   +1 more source

DNA Adduct Formation of 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline in Mouse Liver and Extrahepatic Tissues During a Subchronic Feeding Study [PDF]

, 2013
Yijin Tang, Fekadu Kassie, Xuemin Qian, Buzayew Ansha, Robert J. Turesky   +4 more
openalex   +1 more source

Supplementary Figures 1 - 5 from Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone–Induced Lung Tumorigenesis in Association with Reducing <i>O⁶</i>-methylguanine DNA Adduct in A/J Mice

, 2023
Pablo Leitzman, Sreekanth C. Narayanapillai, Silvia Balbo, Bo Zhou, Pramod Upadhyaya, Ahmad Ali Shaik, Maeve O’Sullivan, Stephen S. Hecht, Junxuan Lü, Chengguo Xing   +9 more
openalex   +2 more sources

Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer [PDF]

, 2017
Irina G. Minko, Carmelo J. Rizzo, R. Stephen Lloyd   +2 more
openalex   +1 more source

Spatial mapping of the DNA adducts in cancer. [PDF]

DNA Repair (Amst), 2023
Krieger KL, Mann EK, Lee KJ, Bolterstein E, Jebakumar D, Ittmann MM, Dal Zotto VL, Shaban M, Sreekumar A, Gassman NR.   +9 more
europepmc   +1 more source

DNA Adducts with Lipid Peroxidation Products [PDF]

Journal of Biological Chemistry, 2008
Homolytic decomposition of PUFA2-derived lipid hydroperoxides results in formation of the α,β-unsaturated aldehydic bifunctional electrophiles DDE, EDE, HNE, HPNE, MDA (shown as β-hydroxyacrolein), ONE, DODE, and 5,8-dioxo-(10E)-octenoic acid (see Fig. 1) (1–3).
openaire   +2 more sources

Repair of Retrorsine-Induced DNA Damage in Rat Livers: Insights Gained from Transcriptomic and Proteomic Studies

Toxins
Pyrrolizidine alkaloids (PAs) are common phytotoxins that are found worldwide. Upon hepatic metabolic activation, the reactive PA metabolites covalently bind to DNAs and form DNA adducts, causing mutagenicity and tumorigenicity in the liver. However, the
Yun Long, Yiwei Wang, Zijing Song, Xin He, Yisheng He, Ge Lin   +5 more
doaj   +1 more source

A Mathematical Model for DNA Damage and Repair

Journal of Nucleic Acids, 2010
In cells, DNA repair has to keep up with DNA damage to maintain the integrity of the genome and prevent mutagenesis and carcinogenesis. While the importance of both DNA damage and repair is clear, the impact of imbalances between both processes has not ...
Philip S. Crooke, Fritz F. Parl
doaj   +1 more source

RAD54L2 counters TOP2-DNA adducts to promote genome stability. [PDF]

Sci Adv, 2023
D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP.   +16 more
europepmc   +1 more source