Results 81 to 90 of about 2,170,594 (309)
Environmental Health Perspectives, 2012 Background: Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic environmental pollutants generated during incomplete combustion. After exposure and during metabolism, PAHs can form reactive epoxides that can covalently bind to DNA.
J. Herbstman +7 more
semanticscholar +1 more source
Site-specific DNA substrates for human excision repair: comparison between deoxyribose and base adducts [PDF]
, 1996 Background: The genetic integrity of living organisms is maintained by a complex network of DNA repair pathways. Nucleotide excision repair (NER) is a versatile process that excises bulky base modifications from DNA.
Giese, Bernd +4 more
core +1 more source
DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
AIMS Genetics, 2017 Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects.
Fabrizio Gentile +9 more
doaj +1 more source
环境与职业医学, 2022 BackgroundThe incidence rate of missed abortion is increasing year by year, but the etiology has not been fully elucidated. Adverse pregnancy history and exposure to polycyclic aromatic hydrocarbons (PAHs) may increase the risk of missed abortion ...
Jiayu ZHANG +6 more
doaj +1 more source
Cyclization of Short DNA Fragments [PDF]
Physica A482, 569 (2017), 2017 From the per unit length free energy for DNA under tension, we have calculated an effective contour length dependent persistence length for short DNA. This effective persistence length results from the enhanced fluctuations in short DNA. It decreases for shorter DNA, making shorter DNA more flexible.
arxiv +1 more source
ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair [PDF]
, 2008 Background: The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the resistant cell lines have a cell
A Husain +43 more
core +2 more sources
Defects Can Increase the Melting Temperature of DNA-Nanoparticle Assemblies [PDF]
J. Phys. Chem. B, 110 (2006) 16393-16396, 2007 DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable detection technology.
arxiv +1 more source
Estrogens as endogenous genotoxic agents--DNA adducts and mutations.
Journal of the National Cancer Institute. Monographs, 2000 Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. In relation to the role of estrogens in the induction of cancer, we examine formation of DNA adducts by reactive electrophilic estrogen ...
E. Cavalieri +4 more
semanticscholar +1 more source
Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]
, 2009 The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core +1 more source
Chemical Research in Toxicology, 2012 Aristolochic acids (AAs) are a structurally related family of nephrotoxic and carcinogenic nitrophenanthrene compounds found in Aristolochia herbaceous plants, many of which have been used worldwide for medicinal purposes. AAs have been implicated in the
B. Yun +10 more
semanticscholar +1 more source