Results 111 to 120 of about 86,225 (296)

Anthropogenic Pressures, Rather Than Plant Vigour, Promote Insect Herbivory Rates on Securidaca longepedunculata Along Elevation in a South African Woodland

Ecology and Evolution
Understanding why some plants experience greater herbivory than others is central to predicting population dynamics and ecosystem resilience. We tested the plant vigour hypothesis, the resource concentration hypothesis and the role of anthropogenic ...
Mashudu Patience Mamathaba, Bopaki Phogole, Orou G. Gaoue, Kowiyou Yessoufou   +3 more
doaj   +1 more source

Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway

Frontiers in Pharmacology
IntroductionBenign prostatic hyperplasia (BPH) is the enlargement of the prostate gland, primarily occurring in aging men, in which transforming growth factor-beta (TGF-β) plays a critical role in prostate cell hyperproliferation and leads to ...
San Yoon Nwe, San Yoon Nwe, San Yoon Nwe, Tamonwan Uttarawichien, Tamonwan Uttarawichien, Teerawat Boonsom, Teerawat Boonsom, Wisuwat Thongphichai, Wisuwat Thongphichai, Peththa Wadu Dasuni Wasana, Peththa Wadu Dasuni Wasana, Boonchoo Sritularak, Boonchoo Sritularak, Witchuda Payuhakrit, Suchada Sukrong, Suchada Sukrong, Pasarapa Towiwat, Pasarapa Towiwat   +17 more
doaj   +1 more source

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis [PDF]

, 2019
Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Studies in rodent models demonstrated an association of CNS-infiltrating monocyte-derived macrophages with disease severity ...
Asseyer, Susanna, Böttcher, Chotima, Fernández-Zapata, Camila, Gieß, René M., Kunkel, Desiree, Mei, Henrik E., Paul, Friedemann, Priller, Josef, Ruprecht, Klemens, Schlickeiser, Stephan, Schulz, Axel R., Siegmund, Britta, Weidinger, Carl   +12 more
core   +2 more sources

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Sampling Local Fungal Diversity in an Undergraduate Laboratory using DNA Barcoding [PDF]

, 2014
Traditional methods for fungal species identification require diagnostic morphological characters and are often limited by the availability of fresh fruiting bodies and local identification resources.
Anderson, B. W., Bigott, A. F., Boone, M. J., Brick, S. M., delSol, J. F., Harrington, A. H., Hotchkiss, R. A., Huddleston, R. A., Kasper, E. H., McGrady, J. J., McKinnie, M. L., Ottenlips, M. V., Skinner, N. E., Spatz, K. C., Steinberg, A. J., van den Broek, F., Willyard, A. M., Wilson, C. N., Wofford, A. M   +18 more
core   +3 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Exploring the safety of lycorine in the central nervous system and its impact on pain-like behaviors in mice

Scientific Reports
Alkaloid analgesics have been associated with adverse effects on the central nervous system (CNS). Therefore, it is crucial to characterize the effects of alkaloid analgesics.
Hasriadi Hasriadi, Peththa Wadu Dasuni Wasana, Wisuwat Thongphichai, Suchada Sukrong, Pasarapa Towiwat   +4 more
doaj   +1 more source

Integrative geno-metabolomics of tenasserim turmeric (Curcuma candida (Wall.) Techapr. & Škorničk.) with insights into volatile biosynthesis across the turmeric genus

Computational and Structural Biotechnology Journal
Tenasserim turmeric (Curcuma candida), an edible species native to the Tenasserim Range along the Thailand-Myanmar border, has been traditionally consumed as a vegetable.
Pantamith Rattanakrajang, Rossarin Tansawat, Pornpimon Wongsuwan, Nattapon Nopporncharoenkul, Supaart Sirikantaramas, Suchada Sukrong   +5 more
doaj   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source