Results 141 to 150 of about 53,036 (303)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Photoactivated Signaling Networks using DNA‐Based Synthetic Organelles as Biomimetic Protocells

Angewandte Chemie, EarlyView.
Light‐triggered intercommunication between two types of organelle‐loaded liposomes lead to DNAzyme‐mediated on transcription‐guided structural reconfiguration of the organelles. ABSTRACT Membraneless organelles formed by phase‐separated nucleic acid or protein condensates play vital roles in regulating cellular functions.
Huiying Xue, Yunlong Qin, Yichen Han, Shijun Xu, Itamar Willner, Fan Xia, Fujian Huang   +6 more
wiley   +2 more sources

Utilization of Barcode for examining authenticity of species/origin-labels for the processed skates and rays in the market.

, 2010
Skates are commercially important fish species in Korea. Especially, Raja pulchra enjoys high consumer preference and a high price than compared to other Raja species because of its better taste.
정다금, 김충곤, 이윤호
core   +1 more source

Traceability of Agri‐Food Products: The Key to Conscious Trade

Agribusiness, EarlyView.
ABSTRACT Globalization and growing concerns about sustainability have led to improvements in product traceability, quality, and sustainability. Traceability contributes to environmental protection and supports sustainable development by fostering transparency in agricultural practices and encouraging the responsible use of resources.
Scarlett Queen Almeida Bispo, Fernanda Aparecida Silva, Michelle Márcia Viana Martins, Marcelo José Braga Nonnenberg, Ruan da Silva Vianna, Carla Cristina Passos Cruz   +5 more
wiley   +1 more source

Expanding High‐Fidelity Multiplexing in Ultrasensitive Single‐Molecule Protein Detection via Proximity Barcoding

Angewandte Chemie, EarlyView.
We develop an ultrasensitive, high‐accuracy multiplex protein detection platform integrating high‐throughput single‐molecule protein detection with proximity ligation. Using paired DNA barcodes, this platform breaks the digital immunoassay multiplexing ceiling imposed by cross‐reactivity and fluorescence spectral overlap, providing a broadly accessible
Chi‐Chia Wang, Emily Dorsey, Connie Wu
wiley   +2 more sources

Evaluating the Conduciveness of the Policy Environment for Deploying Sustainable Renewable Energy Mini-Grids in Lesotho

Energies
Universal electricity access remains elusive in Lesotho, with only a 53% connection rate. This statistic highlights a significant urban–rural gap of 60% to 18%, favouring urban areas mainly served by the main grid.
Ntelekoa Masiane, Nnamdi Nwulu, Kowiyou Yessoufou   +2 more
doaj   +1 more source

Update and validation of DNA Barcoding protocols by end-users (DNA Barcoding)

, 2013
Slide of the Euphresco project 'Update and validation of DNA Barcoding protocols by end-users' (DNA Barcoding)Project funded through the Euphresco ...
van de Vossenberg, Bart (8268612), van de Vossenberg, Bart   +1 more
core   +1 more source

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Exploring the lichenization continuum through the marine tripartite symbiosis of Collemopsidium pelvetiae

American Journal of Botany, EarlyView.
Abstract Premise Symbioses between lichen‐forming fungi and brown algae (phaeophytes) are extremely rare. We investigated the interactions between the marine fungus Collemopsidium pelvetiae and its two photosynthetic partners, the brown alga Pelvetia canaliculata and a cyanobacterial symbiont to address questions on symbiosis biology, lichenization ...
Sergio Pérez‐Ortega, Rúdiger Ortiz‐Álvarez, Jacek Wierzchos, Miguel Blázquez, Alain Gérault, Asunción de los Ríos   +5 more
wiley   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source