Results 91 to 100 of about 353,576 (232)

Implications of mtDNA in human health and diseases

BioTechnologia
The maternally inherited autonomous organelles, mitochondria, are responsible for a myriad of functions within the cell. They may contain more than one copy of DNA and can themselves be present in multiple numbers within a cell.
Smruthi Seethashankar, Shruti Hariharan, Venkatachalam Deepa Parvathi   +2 more
doaj   +1 more source

Absolute measurement of gene transcripts with Selfie-digital PCR

Scientific Reports, 2017
Absolute measurement of the number of RNA transcripts per gene is necessary to compare gene transcription among different tissues or experimental conditions and to assess transcription of genes that have a variable copy number per cell such as ...
Petar Podlesniy, Ramon Trullas
doaj   +1 more source

Identification and characterization of copy number variations (CNVs) in dengue patients and its impact with vascular leakage / Zuraihan Zakaria [PDF]

, 2016
Dengue fever is a mosquito-borne tropical disease caused by dengue virus. When infected by any of the four serotypes of dengue viruses, individuals may be asymptomatic or develop a dengue fever.
Zakaria, Zuraihan
core  

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]

, 2013
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ, Greene, M, Linedale, R, McKendrick, IJ, Sales, J, Schock, A, Sharp, JM, Stevenson, K   +7 more
core   +1 more source

Systematic biases in DNA copy number originate from isolation procedures

Genome Biology, 2013
BackgroundThe ability to accurately detect DNA copy number variation in both a sensitive and quantitative manner is important in many research areas.
Sebastiaan van Heesch, M. Mokry, V. Boskova, Wade M. Junker, Rajdeep Mehon, Pim W. Toonen, Ewart de Bruijn, J. Shull, T. Aitman, E. Cuppen, V. Guryev   +10 more
semanticscholar   +1 more source

Surviving a Genome Collision: Genomic Signatures of Allopolyploidization in the Recent Crop Species [PDF]

, 2017
Polyploidization has played a major role in crop plant evolution, leading to advantageous traits that have been selected by humans. Here, we describe restructuring patterns in the genome of Brassica napus L., a recent allopolyploid species.
Chalhoub, Boulos, Samans, Birgit, Snowdon, Rod J.   +2 more
core   +1 more source

Genes with Relevance for Early to Late Progression of Colon Carcinoma Based on Combined Genomic and Transcriptomic Information from the Same Patients

Cancer Informatics, 2010
Background Genetic and epigenetic alterations in colorectal cancer are numerous. However, it is difficult to judge whether such changes are primary or secondary to the appearance and progression of tumors.
Kristina K. Lagerstedt, Erik Kristiansson, Christina Lönnroth, Marianne Andersson, Britt-Marie IresjÖ, Annika Gustafsson, Elisabeth Hansson, Ulf Kressner, Svante Nordgren, Fredrik Enlund, Kent Lundholm   +10 more
doaj   +2 more sources

DNA alterations in Cd133+ and Cd133- tumour cells enriched from intra-operative human colon tumour biopsies

BMC Cancer, 2017
Background Tumour stem cells are considered important to promote disease progression, recurrence and treatment resistance following chemotherapy in colon cancer.
Diana Cervantes-Madrid, Yvonne Wettergren, Peter Falk, Kent Lundholm, Annika G. Asting   +4 more
doaj   +1 more source

Evaluation of D-loop hypervariable region I variations, haplogroups and copy number of mitochondrial DNA in Bangladeshi population with type 2 diabetes [PDF]

, 2021
Sajoy Kanti Saha, Abdullah Al Saba, Md. Hasib, Razoan Al Rimon, Imrul Hasan, Md Sohrab Alam, Ishtiaq Mahmud, AHM Nurun Nabi   +7 more
openalex   +1 more source

Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: a prospective study

OncoTarget, 2017
The aim of the present study was to establish a rapid profiling method using multiplex ligation-dependent probe amplification (MLPA) and characterize copy number variations (CNV) in circulating, cell-free DNA (cfDNA) in 85 urothelial carcinoma of the ...
A. Soave, F. Chun, T. Hillebrand, M. Rink, L. Weisbach, B. Steinbach, M. Fisch, K. Pantel, H. Schwarzenbach   +8 more
semanticscholar   +1 more source