Results 21 to 30 of about 5,698,803 (355)
Communications Biology, 2023 The Schlafen (SLFN)11 gene has been implicated in various biological processes such as suppression of HIV replication, replication stress response, and sensitization of cancer cells to chemotherapy.
Erin Alvi +7 more
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MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer
Cancer Cell International, 2021 Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation ...
Tong Niu, Weiwei Zhang, Wei Xiao
doaj +1 more source
DNA damage—how and why we age?
eLife, 2021 Aging is a complex process that results in loss of the ability to reattain homeostasis following stress, leading, thereby, to increased risk of morbidity and mortality.
Matthew J. Yousefzadeh +5 more
semanticscholar +1 more source
Cells, 2021 The clustered DNA lesions (CDLs) are a characteristic feature of ionizing radiation’s impact on the human genetic material. CDLs impair the efficiency of cellular repair machinery, especially base excision repair (BER).
Karolina Boguszewska +3 more
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ULK1 in autophagy: sugar it up
Autophagy Reports, 2022 Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
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The Influence of 5′R and 5′S cdA and cdG on the Activity of BsmAI and SspI Restriction Enzymes
Molecules, 2021 Restriction endonucleases (REs) are intra-bacterial scissors that are considered tools in the fight against foreign genetic material. SspI and BsmAI, examined in this study, cleave dsDNA at their site of recognition or within a short distance of it. Both
Michał Szewczuk +3 more
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Molecules, 2021 Ionizing radiation is a factor that seriously damages cellular mechanisms/macromolecules, e.g., by inducing damage in the human genome, such as 5′,8-cyclo-2′-deoxypurines (cdPus).
Michał Szewczuk +3 more
doaj +1 more source
Molecules, 2021 The 5′,8-cyclo-2′-deoxypurines (cdPus) affect the DNA structure. When these bulky structures are a part of clustered DNA lesions (CDL), they affect the repair of the other lesions within the cluster.
Karolina Boguszewska +2 more
doaj +1 more source
DNA Damage Atlas: an atlas of DNA damage and repair
Nucleic Acids Research, 2023 DNA damage and its improper repair are the major source of genomic alterations responsible for many human diseases, particularly cancer. To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide ...
Yu Liang +9 more
semanticscholar +1 more source
BioTechniques, 2014 Here we describe the adaptation of laser scanning cytometry (LSC) to measure micronuclei (MN) automatically in lymphocytes. MN frequencies were determined in irradiated human lymphocytes using the cytokinesis-block technique, and the results from LSC ...
Maxime François +3 more
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