Results 21 to 30 of about 5,360,965 (412)

How (5′S) and (5′R) 5′,8-Cyclo-2′-Deoxypurines Affect Base Excision Repair of Clustered DNA Damage in Nuclear Extracts of xrs5 Cells? A Biochemical Study

open access: yesCells, 2021
The clustered DNA lesions (CDLs) are a characteristic feature of ionizing radiation’s impact on the human genetic material. CDLs impair the efficiency of cellular repair machinery, especially base excision repair (BER).
Karolina Boguszewska   +3 more
doaj   +1 more source

ULK1 in autophagy: sugar it up

open access: yesAutophagy Reports, 2022
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
doaj   +1 more source

Molecular rectifiers with very high rectification ratio enabled by oxidative damage in double-stranded DNA [PDF]

open access: yesJ. Phys. Chem. B 2022, 126, 25, 4636-4646, 2022
In this work, we report a novel strategy to construct molecular diodes with a record tunable rectification ratio of as high as 10^6 using oxidatively damaged DNA molecules. Being exposed to several endogenous and exogenous events, DNA suffers constant oxidative damages leading to oxidation of guanine to 8-Oxoguanine (8oxoG).
arxiv   +1 more source

The Influence of 5′,8-Cyclo-2′-deoxypurines on the Mitochondrial Repair of Clustered DNA Damage in Xrs5 Cells: The Preliminary Study

open access: yesMolecules, 2021
The 5′,8-cyclo-2′-deoxypurines (cdPus) affect the DNA structure. When these bulky structures are a part of clustered DNA lesions (CDL), they affect the repair of the other lesions within the cluster.
Karolina Boguszewska   +2 more
doaj   +1 more source

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

open access: yesSignal Transduction and Targeted Therapy, 2020
Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications.
Rui-Xue Huang, P. Zhou
semanticscholar   +1 more source

DNA damage and autophagy [PDF]

open access: yesMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2011
Both exogenous and endogenous agents are a threat to DNA integrity. Exogenous environmental agents such as ultraviolet (UV) and ionizing radiation, genotoxic chemicals and endogenous byproducts of metabolism including reactive oxygen species can cause alterations in DNA structure (DNA damage). Unrepaired DNA damage has been linked to a variety of human
Mihalis I. Panayiotidis   +3 more
openaire   +3 more sources

The Usefulness of Autoradiography for DNA Repair Proteins Activity Detection in the Cytoplasm towards Radiolabeled Oligonucleotides Containing 5′,8-Cyclo-2′-deoxyadenosine

open access: yesChemosensors, 2022
Autoradiography of 32P-radiolabeled oligonucleotides is one of the most precise detection methods of DNA repair processes. In this study, autoradiography allowed assessing the activity of proteins in the cytoplasm involved in DNA repair. The cytoplasm is
Karolina Boguszewska   +2 more
doaj   +1 more source

Electronic Excitation Response of DNA to High-energy Proton Radiation in Water [PDF]

open access: yesPhysical Review Letters 130, 118401 (2023), 2023
The lack of molecular-level understanding for the electronic excitation response of DNA to charged particle radiation, such as high-energy protons, remains a fundamental scientific bottleneck in advancing proton and other ion beam cancer therapies.
arxiv   +1 more source

Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder [PDF]

open access: yes, 2015
Background: Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects a large percentage of the world population.
Bielecka-Kowalska, Anna   +9 more
core   +1 more source

Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]

open access: yes, 2020
DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan   +2 more
core   +1 more source

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