Results 191 to 200 of about 1,712,707 (295)

Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis. [PDF]

Chem Biol Interact
Aishwarya S, Torres GC, Lopez-Saenz JA, Gutierrez DA, Kumar S, Madarakhandi A, Metikurki B, Teraiya N, Aguilera RJ, Karki SS.   +9 more
europepmc   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Influence of the ATP-dependent DNA ligase, Lig E, on <i>Neisseria gonorrhoeae</i> microcolony and biofilm formation. [PDF]

Biofilm
Pan J, Albarrak A, Hicks J, Williams D, Williamson A.   +4 more
europepmc   +1 more source

Post-replicative nick translation occurs on the lagging strand during prolonged depletion of DNA ligase I in Saccharomyces cerevisiae. [PDF]

G3 (Bethesda), 2021
Koussa NC, Smith DJ.
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Rare variants of DNA ligase 1 show distinct mechanisms of deficiency. [PDF]

J Biol Chem
Veenstra JH, Chabez A, Haanen TJ, Keranen A, Cunningham-Rundles C, O'Brien PJ.   +5 more
europepmc   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

DNA Ligase I Circularises Potato Spindle Tuber Viroid RNA in a Biomolecular Condensate. [PDF]

Mol Plant Pathol
Wang Y, Ma J, Hao J, Liu B, Wang Y.
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Redundant but essential functions of PARP1 and PARP2 in DNA ligase I-independent DNA replication. [PDF]

Nucleic Acids Res
Bhandari SK, Wiest N, Sallmyr A, Du R, Tomkinson AE.   +4 more
europepmc   +1 more source