Results 281 to 290 of about 5,610,569 (399)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Cost-Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers. [PDF]

Adv Sci (Weinh)
Yang T, Wang M, Wang N, Pan M, Xu Y, You Q, Yao L, Xu J, Gu L, Sun X, Zhang L, Xu J, Li B, Wang G, Cai S, Lv G, Shen F.   +16 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genetic Diversity and Population Structure of Largefin Longbarbel Catfish (<i>Hemibagrus macropterus</i>) Inferred by mtDNA and Microsatellite DNA Markers. [PDF]

Animals (Basel)
Hou Y, Ye H, Yue H, Li J, Huang L, Qu Z, Ruan R, Lin D, Liang Z, Xie Y, Li C.   +10 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Methylated DNA Markers in Voided Urine for the Identification of Clinically Significant Prostate Cancer. [PDF]

Life (Basel)
Shah P, Taylor WR, Negaard BJ, Gochanour BR, Mahoney DW, Then SS, Devens ME, Foote PH, Doering KA, Burger KN, Nikolai B, Kaiser MW, Allawi HT, Cheville JC, Kisiel JB, Gettman MT.   +15 more
europepmc   +1 more source

5-Hydroxymethylcytosine signatures in circulating cell-free DNA as potential diagnostic markers for breast cancer

Nadire Aishan, Siwei Ju, Zhongqiu Zheng, Yongxia Chen, Qingna Meng, Qina He, Jiahang Zhang, Jiaheng Lang, Bojian Xie, Lidan Jin, Jun Shen, Yi Lu, Yangjun Cai, Feiyang Ji, Feilin Cao, Linbo Wang   +15 more
openalex   +2 more sources

Genetic diversity analysis of endemic species, Garcinia cambogia Gaertn using randomly amplified Polymorphic DNA markers

, 2017
P Santosh, Suresh B. Arakera
openalex   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Development of DNA Markers to Resolve Uncertainties of Seabird Bycatch Identification From Longline Fisheries in Australian Waters. [PDF]

Ecol Evol
Polanowski AM, MacDonald AJ, Double MC, Barrington JHS, Burg TM, Wienecke B, McInnes JC.   +6 more
europepmc   +1 more source