Results 161 to 170 of about 410,424 (355)

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Multi‐readout thermoplasmonic biosensor for rapid detection of oligonucleotides

View
Developing user‐friendly, high‐performance sensing devices for nucleic acid detection is crucial for diagnostics, drug development, and personalized therapies.
Maria Laura Sforza, Elisabetta De Marinis, Annalisa Masi, Clara Nervi, Luciano De Sio, Francesca Petronella   +5 more
doaj   +1 more source

Simultaneous Detection of Mycobacterium tuberculosis and Atypical Mycobacteria by DNA-Microarray in Egypt. [PDF]

Med Princ Pract, 2022
Gaballah A, Ghazal A, Almiry R, Emad R, Sadek N, Abdel Rahman M, El-Sherbini E.   +6 more
europepmc   +1 more source

Distinct CTC Specific RNA Profile Enables NSCLC Early Detection and Dynamic Monitoring of Advanced NSCLC

Advanced Science, EarlyView.
A quantitative CTC RNA assay is developed by incorporating multi‐antibody‐based CTC isolation and specific mRNA quantification using RT‐ddPCR. The NSCLC CTC ScoreD demonstrates high accuracy for early‐stage NSCLC detection, significantly outperforming serum CEA. NSCLC CTC ScoreM exhibits a more accurate early‐warning of responses to different therapies
Xiaoyu Wang, Pi Ding, Wenjuan Xu, Lei Qiu, Jing Ren, Yucheng Fei, Zhili Wang, Cheng Li, Yufei Xing, Mingjing Shen, Yawen Zhu, Yun Guo, Na Sun, Renjun Pei, Minhua Shi   +14 more
wiley   +1 more source

Comparative Study of Classification Algorithms for Various DNA Microarray Data. [PDF]

Genes (Basel), 2022
Kim J, Yoon Y, Park HJ, Kim YH.
europepmc   +1 more source

Examining the Living Genome in Health and Disease With DNA Microarrays [PDF]

, 2000
Maximilian Diehn, Ash A. Alizadeh, Patrick O. Brown   +2 more
openalex   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Microarray Applications in Neuroscience

Neurobiology of Disease, 2001
Advances in all facets of technology from molecular biology to imaging and computational biology offer unprecedented opportunities for improving our understanding of the brain in health and disease.
Zheng Luo, Daniel H. Geschwind
doaj  

DNA microarray analysis of Staphylococcus aureus from Nigeria and South Africa. [PDF]

PLoS One, 2021
Shittu AO, Adesoji T, Udo EE.
europepmc   +1 more source

Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration [PDF]

, 2003
Mammalian skeletal muscles are capable of regeneration after injury. Quiescent satellite cells are activated to reenter the cell cycle and to differentiate for repair, recapitulating features of myogenesis during embryonic development.
Choi, Sangdun, Hart, Rebecca, Lee, Sun Young, Lin, Ling, Liu, Xuebin, Schageman, Jeoffrey J., Thurmond, Frederick A., Williams, R. Sanders, Yan, Zhen, Zhang, Mei   +9 more
core   +1 more source