Results 181 to 190 of about 2,596,459 (367)

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Structure and Oligonucleotide Binding Efficiency of Differently Prepared Click Chemistry-Type DNA Microarray Slides Based on 3-Azidopropyltrimethoxysilane. [PDF]

Materials (Basel), 2021
Frydrych-Tomczak E, Ratajczak T, Kościński Ł, Ranecka A, Michalak N, Luciński T, Maciejewski H, Jurga S, Lewandowski M, Chmielewski MK.   +9 more
europepmc   +1 more source

XPC Deficiency Activate Cisplatin‐Mediated Autophagy in Bladder Cancer by Limiting Novel PHRF1‐Mediated Ubiquitination of the p53 Protein

Advanced Science, EarlyView.
This study reveals that XPC regulates autophagy signaling beyond its noncanonical DNA repair role, uncovering the XPC‐p‐ATM‐KDM4A‐PHRF1 axis as a novel mechanism for autophagy modulation under DNA damage stress. It identifies PHRF1 as a novel p53 ubiquitin ligase.
Baixiong Zhao, Yaqin Huang, Jiazhong Shi, Xiaozhou Zhou, Johan Bourghardt Fagman, Liwei Wang, Sha Liu, Wuxing Wang, Yuting Liu, Zhiwen Chen, Jin Yang   +10 more
wiley   +1 more source

Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: Identification of genes absent from epidemic strains [PDF]

, 2008
Audrey J. King, Tamara van Gorkom, Jeroen L. A. Pennings, Han GJ van der Heide, Qiushui He, Dimitri A. Diavatopoulos, Kees Heuvelman, Marjolein van Gent, Karin van Leeuwen, Frits R. Mooi   +9 more
openalex   +1 more source

Automated cDNA Microarray Segmentation using Independent Component Analysis Algorithm

Applied Medical Informatics, 2015
There is a most useful method in order to simultaneously study thousands of gene expression levels of a simple experiment, called DNA microarray. The average value of fluorescent intensity can be calculated through a microarray experiment. The calculated
Elahe AMINIAN , Shayan YAZDANI, Hamidreza SABERKARI   +2 more
doaj  

DNA Microarray-Based Global Gene Expression Profiling in Human Amniotic Epithelial Cells Predicts the Potential of Microalgae-Derived Squalene for the Nervous System and Metabolic Health. [PDF]

Biomedicines, 2021
Ferdousi F, Furuya K, Sasaki K, Zheng YW, Oda T, Isoda H.   +5 more
europepmc   +1 more source

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

DNA/DNA hybridization to microarrays reveals gene-specific differences between closely related microbial genomes

, 2001
Alison E. Murray, Douglas P. Lies, G. Li, Kenneth H. Nealson, Jizhong Zhou, James M. Tiedje   +5 more
openalex   +1 more source