Results 301 to 310 of about 2,563,210 (334)

The preparation and clinical application of diagnostic DNA microarray for the detection of pathogens in intracranial bacterial and fungal infections. [PDF]

Exp Ther Med, 2018
Cao J, Gao S, Chen J, Zhu B, Min R, Wang P.   +5 more
europepmc   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

Nanodroplet‐Array‐Plattform zur integrierten Synthese und Screening von MEK Inhibitoren: Ein miniaturisierter Ansatz für die frühe Pharmaforschung

Angewandte Chemie, EarlyView.
Wir präsentieren eine Nanodroplet‐Array‐Plattform, die die Integration von Festphasensynthese, MALDI‐MS‐Analyse und zellbasiertem Screening von 325 potenziellen MEK‐Inhibitoren (Mitogen‐aktivierte‐Proteinkinase‐Kinase) in Nanoliter‐Volumina ermöglicht.
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

DNA Microarray Analysis of Estrogen Responsive Genes in Ishikawa Cells by Glabridin. [PDF]

Biochem Insights, 2017
Melissa PSW, Phelim YVC, Navaratnam V, Yoke Yin C.   +3 more
europepmc   +1 more source

Interaktomanalyse einer Lysindeacetylase‐Sondenbibliothek deckt Wechselwirkung zwischen HDAC6 und dem NF‐κB‐Signalweg auf

Angewandte Chemie, EarlyView.
Wir haben eine Peptidsondenbibliothek entwickelt, die auf Substraten der Lysindeacetylase HDAC6 und Hydroxamsäuren basiert. Mit Hilfe dieser konnten wir durch Interaktomanalysen neue HDAC6‐Interaktoren identifizieren. Unter ihnen befand sich der Transkriptionsfaktor NF‐κB, wobei wir zeigen konnten, dass HDAC6 der Aktivität von acetyliertem NF‐κB p50 ...
Julian Seidel, Caroline Schönfeld, Julia Sindlinger, Jürgen Eirich, Sören Kirchgäßner, Nina Kreienkamp, Klaus Schulze‐Osthoff, Iris Finkemeier, Stephan Hailfinger, Dirk Schwarzer   +9 more
wiley   +1 more source

Identification and analysis of key genes associated with ulcerative colitis based on DNA microarray data. [PDF]

Medicine (Baltimore), 2018
Song R, Li Y, Hao W, Wang B, Yang L, Xu F.   +5 more
europepmc   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

DNA microarray integromics analysis platform. [PDF]

BioData Min, 2015
Waller T, Gubała T, Sarapata K, Piwowar M, Jurkowski W.   +4 more
europepmc   +1 more source

Interactome Profiling of a Lysine Deacetylase Trapping Probe Library Uncovers Crosstalk Between HDAC6 and NF‐κB Signaling

Angewandte Chemie International Edition, EarlyView.
We designed a peptide probe library containing hydroxamic acids based on putative substrate sites of lysine deacetylase HDAC6. Analyzing substrate selectivity and turnover combined with proteomics profiling resulted in identification of novel HDAC6 interaction partners, such as components of the transcription factor NF‐κB.
Julian Seidel, Caroline Schönfeld, Julia Sindlinger, Jürgen Eirich, Sören Kirchgäßner, Nina Kreienkamp, Klaus Schulze‐Osthoff, Iris Finkemeier, Stephan Hailfinger, Dirk Schwarzer   +9 more
wiley   +1 more source

Technological Innovations and Applications of Spatial Transcriptomics in Livestock and Poultry Research

Animal Research and One Health, EarlyView.
The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang, Ao Guo, Lin Zhang, Shengru Wu, Juan Du, Taiyong Yu   +5 more
wiley   +1 more source