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Fabrication of DNA Microarray [PDF]
, 2008 There are many ways to fabricate DNA microarrays. The four main types of arrays are spotted arrays of pre-made DNA probes, in situ synthesis of DNA arrays, random bead arrays and suspension arrays. The different types of array can address different biological assays.
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Current Opinion in Oncology, 2003
Since the discovery of the first oncogene 26 years ago, a large body of research has convincingly demonstrated that the initiation and progression of cancers involve the accumulation of genetic aberrations in the cell. Many techniques have been developed to identify these genetic abnormalities.
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Since the discovery of the first oncogene 26 years ago, a large body of research has convincingly demonstrated that the initiation and progression of cancers involve the accumulation of genetic aberrations in the cell. Many techniques have been developed to identify these genetic abnormalities.
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Protein Microarrays Printed from DNA Microarrays
2010Protein arrays are miniaturised and highly parallelised formats of interaction-based functional protein assays. Major bottlenecks in protein microarraying are the limited availability and high cost of purified, functional proteins for immobilisation and the limited stability of immobilised proteins in their functional state. In contrast, protein-coding
Oda Stoevesandt +2 more
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Producing Protein Microarrays from DNA Microarrays
2011The development of protein microarrays makes possible interaction-based protein assays in miniaturised, multiplexed formats. A major requirement determining their uptake and use is the availability and stability of purified, functional proteins for immobilisation.
Oda Stoevesandt +2 more
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Immobilization of DNA on Microarrays
2005Microarrays are new analytical devices that allow the parallel and simultaneous detection of thousands of target compounds. Microarrays, also called DNA chips, are widely used in gene expression, the genotyping of individuals, point mutations, detection of single nucleotide polymorphisms, and short tandem repeats.
Heise, Christian, Bier, Frank Fabian
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2009
The completion of the Human Genome Project and the emergence of high-throughput technologies at the dawn of the new millennium, are rapidly changing the way we approach biological problems. DNA microarrays represent a promising new technological development, widely used for the investigation and identification of genes associated with important ...
Aristotelis Chatziioannou +1 more
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The completion of the Human Genome Project and the emergence of high-throughput technologies at the dawn of the new millennium, are rapidly changing the way we approach biological problems. DNA microarrays represent a promising new technological development, widely used for the investigation and identification of genes associated with important ...
Aristotelis Chatziioannou +1 more
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Analysis of DNA Microarray Data
Current Topics in Medicinal Chemistry, 2004Recent advances in DNA microarray technology have great impact on many areas of biomedical research and pharmacogenomics: discovering novel targets and genes, elucidating signatures of complex diseases, transcriptional profiling of models for diseases, and the development of individually optimized drugs based on differential gene expression patterns ...
Hubert Hackl +4 more
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DNA Content Analysis on Microarrays
2004The genome sequencing of protozoan parasites has facilitated the development of powerful postgenomics tools such as DNA microarrays and revolutionized the study of parasite biology. Large-scale genomic comparisons are useful in identifying the extent of genomic variability among related strains and isolates.
Preetam H. Shah +2 more
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An Introduction to DNA Microarrays
2005Oligonucleotide and DNA arrays, or microarrays, have proven to be useful tools to investigate biological function, and are the focal point of an increasing number of studies. However, most papers shed little light on the underlying basis and best use of microarray technology, often leaving a number of important questions unanswered.
Patrick McConnell +2 more
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DNA Microarray-Based Diagnostics
2016The DNA microarray technology is currently a useful biomedical tool which has been developed for a variety of diagnostic applications. However, the development pathway has not been smooth and the technology has faced some challenges. The reliability of the microarray data and also the clinical utility of the results in the early days were criticized ...
Abootaleb Sedighi +2 more
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