Results 291 to 300 of about 297,565 (330)

New trend in molecular diagnostics: Insights from the tumor microenvironment

Interdisciplinary Medicine, EarlyView.
The graphical abstract outline the key elements in TME‐based molecular diagnostics, including biomarker exploration, diagnostic methods, and diagnostic models. Source: Created with BioRender.com. Abstract Molecular diagnosis has revolutionized cancer precision medicine.
Baiyuan Fan, Jiahui Zhang, Chong Li, Xu Zhang   +3 more
wiley   +1 more source

Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes. [PDF]

Hum Genomics
Lei H, Li J, Zhao B, Kou SH, Xiao F, Chen T, Wang SM.   +6 more
europepmc   +1 more source

mtFFPECleaner: A high‐fidelity machine learning approach for artifact removal in high‐throughput mitochondrial DNA sequencing data of archival formalin‐fixed paraffin‐embedded specimens

Interdisciplinary Medicine, EarlyView.
mtFFPECleaner is a high‐fidelity machine learning framework designed to remove formalin‐induced artifacts in mitochondrial DNA sequencing data from formalin‐fixed paraffin‐embedded (FFPE) tissue samples. Using paired FFPE‐fresh‐frozen samples, the model distinguishes genuine mtDNA mutations from artifacts through feature extraction and random forest ...
Shengjing Li, Wenjie Guo, Tianlei Sun, Fanfan Xie, Fan Peng, Kaixiang Zhou, Zhangwen Lei, Xu Guo, Yang Liu, Jinliang Xing   +9 more
wiley   +1 more source

Single cell AI-based detection of DNA mismatch repair deficiency in 1,988 colorectal cancers reveals prognostic and predictive value in the SCOT trial

, 2023
Nowak M, Jabbar F, Rodewald A, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders M, Kerr R, Oein K, Maka N, Hay J, Edwards J, Tomlinson I, Sansom O, Kelly C, Easton A, Domingo E, TransSCOT group, Koelzer VH, Church DN.   +20 more
europepmc   +1 more source

Bcl2 Impedes DNA Mismatch Repair by Directly Regulating the hMSH2-hMSH6 Heterodimeric Complex

, 2007
Yongzhong Hou, Fengqin Gao, Qinhong Wang, Jin‐Feng Zhao, Tammy Flagg, Zhang Yang-de, Xingming Deng   +6 more
openalex   +1 more source

Comparing Imaging Depth of Intravital Lung Imaging Using Perfluorocarbon‐Based Liquid Ventilation With Tissue Clearing for Deep‐Tissue Imaging

Journal of Biophotonics, EarlyView.
Partial liquid ventilation with oxygenized perfluorocarbon (PFC) is used to assess the limitations of imaging depth, caused by the refractive index mismatch between air and surfactants in the mouse lung. PFC does not help to overcome this limitation. Only removing scattering lipids and decolorization ex vivo, with tissue optical clearing, enhance the ...
Pascal Detampel, Wolf Heusermann, Katarzyna M. Wojcik, Bryan G. Yipp, Matthias Amrein   +4 more
wiley   +1 more source

DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma. [PDF]

Oncoimmunology
Xu-Monette ZY, Luo C, Yu L, Li Y, Bhagat G, Tzankov A, Visco C, Fan X, Dybkaer K, Sakhdari A, Wang NT, Yuan AF, Chiu A, Tam W, Zu Y, Hsi ED, Perry AM, Song W, O'Malley D, Au Q, Nunns H, Go H, Møller MB, Parsons BM, Montes-Moreno S, Ponzoni M, Ferreri AJM, Sohani AR, Abramson JS, Xu B, Young KH.   +30 more
europepmc   +1 more source

Mutational analysis of the DNA mismatch repair genes, hMLH1 and hMSH2, in South African colorectal cancer patients

, 2005
Cecilia M. Dorfling
openalex   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source