Results 301 to 310 of about 297,565 (330)

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source

How Middle Managers Affect Frontline Idea Generation: Evidence From Healthcare Operations

Journal of Operations Management, EarlyView.
ABSTRACT This multiple case study develops a mid‐range theory on how frontline idea generation is affected by the actions of an organization's middle management. The study draws from four acute‐care hospitals in Germany and involves 36 semi‐structured interviews with representatives from all hierarchy levels.
Felix L. Mosner, Fabian J. Sting, Aravind Chandrasekaran   +2 more
wiley   +1 more source

Compound heterozygous MSH3 germline variants and associated tumor somatic DNA mismatch repair dysfunction. [PDF]

NPJ Precis Oncol
Koi M, Leach BH, McGee S, Tseng-Rogenski SS, Burke CA, Carethers JM.   +5 more
europepmc   +1 more source

Plankton communities today and tomorrow—potential impacts of multiple global change drivers and marine heatwaves

Limnology and Oceanography, EarlyView.
Abstract In the context of global change, marine organisms are subjected not only to gradual changes in abiotic parameters, but also to an increasing number of extreme events, such as heatwaves. However, we still know little about the influence of heatwaves on the structure of marine communities, and experimental studies are needed to test the impact ...
Cédric L. Meunier, Josefin Schmidt, Antonia Ahme, Areti Balkoni, Katharina Berg, Lea Blum, Maarten Boersma, Jan D. Brüwer, Bernhard M. Fuchs, Luis Gimenez, Maïté Guignard, Ruben Schulte‐Hillen, Bernd Krock, Johannes Rick, Herwig Stibor, Maria Stockenreiter, Simon Tulatz, Felix Weber, Antje Wichels, Karen Helen Wiltshire, Sylke Wohlrab, Inga V. Kirstein   +21 more
wiley   +1 more source

A tale of two pathways: Review of immune checkpoint inhibitors in DNA mismatch repair-deficient and microsatellite instability-high endometrial cancers. [PDF]

Cancer
Liu YL, Weigelt B.
europepmc   +1 more source

Acute and long‐term warming effects on the functional response and reproductive efficiency of marine copepods

Limnology and Oceanography, EarlyView.
Abstract The impact of climate change stressors on marine copepods, key organisms at the base of ocean food webs, remains understudied. This study examined how warming affects their functional and numerical responses, critical life history traits linked to fitness.
Carlos de Juan, Ana Sotomayor‐García, Albert Calbet, Enric Saiz   +3 more
wiley   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

Med Research, EarlyView.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin, Mingjun Lu, Jingwei Guo, Chenyang Wang, Teng Ma   +4 more
wiley   +1 more source

Tumor Budding, p53, and DNA Mismatch Repair Markers in Sinonasal Intestinal-Type Adenocarcinoma: A Retrospective Study Supports the Adverse Prognostic Impact of Tumor Budding. [PDF]

Cancers (Basel)
Puccio S, Azzarello G, Maffeis V, Laurino L, Mairani E, Conte F, Tessari N, Cazzador D, Zanoletti E, Politi D, Emanuelli E, Spinato G, Ausoni S.   +12 more
europepmc   +1 more source

Isolation, cloning and characterisation of motifs containing (GA/TC)n rpeeats from vetch, Vicia bithynica [PDF]

, 2004
Bowater, Richard, Parniewski, Pawel, Sakowicz, Tomasz   +2 more
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