Results 201 to 210 of about 299,286 (332)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reconstructing the lifelong history of cells and tissues via somatic mutation analysis. [PDF]

Cell Mol Life Sci
Faienza S, Margaria JP, Franco I.
europepmc   +1 more source

Mutational analysis of the DNA mismatch repair genes, hMLH1 and hMSH2, in South African colorectal cancer patients

, 2005
Cecilia M. Dorfling
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Genomic Surveillance of 3R Genes Associated with Antibiotic Resistance in <i>Mycobacterium tuberculosis</i> Isolates from Kazakhstan. [PDF]

Antibiotics (Basel)
Timochshuk S, Shamukhan A, Yakupov B, Auganova D, Zein U, Turgimbayeva A, Tarlykov P, Abeldenov S.   +7 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The Temozolomide Mutational Signature: Mechanisms, Clinical Implications, and Therapeutic Opportunities in Primary Brain Tumor Management. [PDF]

Cells
Yaacov A, Gillis R, Salim J, Katz D, Asna N, Paldor I, Grinshpun A.   +6 more
europepmc   +1 more source

SITES OF BREAKAGE IN THE DNA MOLECULE AS DETERMINED BY RECOMBINATION ANALYSIS OF STREPTOMYCIN-RESISTANCE MUTATIONS IN PNEUMOCOCCUS

, 1964
Minna B. Rotheim, Arnold W. Ravin
openalex   +2 more sources

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine. [PDF]

Nucleic Acids Res
Bilardi RA, Flensburg C, Xu Z, Derrick EB, Kueh A, Majewski IJ.   +5 more
europepmc   +1 more source