Results 221 to 230 of about 299,286 (332)

The dynamics of mutational selection in cutaneous squamous carcinogenesis. [PDF]

Commun Biol
Skrupskelyte G, Fowler JC, Dentro S, Winkler C, Abnizova I, Beumer N, Sood R, Quarrell T, King C, Kamarashev J, Guenova E, Gerstung M, Hall BA, Michalik L, Jones PH.   +14 more
europepmc   +1 more source

Application of qPCR-HRM curve analysis and common-PCR with DNA sequencing in detection of EGFR mutations in glioma tissues

, 2012
Shi Zhi-don, Sun Yat-sen
openalex   +1 more source

Functional analysis of H. sapiens DNA polymerase γ spacer mutation W748S with and without common variant E1143G

, 2010
Eino Palin, Annamari Lesonen, Carol L. Farr, Liliya Euro, Anu Suomalainen, Laurie S. Kaguni   +5 more
openalex   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Mitochondrial DNA mutations in head and neck squamous cell carcinoma: a systematic review and meta-analysis. [PDF]

BMC Cancer
Mottaghi M, Jafari F, Nejati M, Farshad F, Khorshidi Asl Z, Azmoudeh F.   +5 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Secondary <i>POLE</i> Mutation Drives Metastasis in Hereditary Breast and Ovarian Cancer: Revealing Fallopian Tube Ultramutation. [PDF]

JCO Precis Oncol
Jisaka M, Nakamura K, Chiyoda T, Iwata T, Masuda K, Kawano R, Funata S, Takamatsu R, Nishihara H, Yamagami W.   +9 more
europepmc   +1 more source

Identification and Mutational Analysis of Mg2+ Binding Site in EcoP15I DNA Methyltransferase

, 2003
Pradeep Bist, Desirazu N. Rao
openalex   +1 more source

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors [PDF]

, 2012
Luı́sa Pereira, Pedro Soares, Valdemar Máximo, David C. Samuels   +3 more
openalex   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source