Results 191 to 200 of about 1,611,597 (332)

Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability.

Proceedings of the National Academy of Sciences of the United States of America, 1995
S. Korolev, M. Nayal, W. M. Barnes, E. Di Cera, G. Waksman   +4 more
semanticscholar   +1 more source

Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters

Arthritis Care &Research, EarlyView.
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US‐based skin assessments for their face validity (differentiation between involved SSc and healthy
Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L. Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin, Maureen Mayes, Shervin Assassi   +12 more
wiley   +1 more source

Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase I. [PDF]

Chem Res Toxicol, 2017
Prakasha Gowda AS, Spratt TE.
europepmc   +1 more source

Role of DNA polymerase I and the rec system in excision-repair in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America, 1972
P. Cooper, P. Hanawalt
semanticscholar   +1 more source

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Optimal numbers of residues in linkers of DNA polymerase I, T7 primase and DNA polymerase IV. [PDF]

Sci Rep, 2016
Fu YB, Wang ZF, Wang PY, Xie P.
europepmc   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli. [PDF]

Sci Rep
Shikazono N, Akamatsu K.
europepmc   +1 more source

Conformational dynamics of Thermus aquaticus DNA polymerase I during catalysis. [PDF]

J Mol Biol, 2014
Xu C, Maxwell BA, Suo Z.
europepmc   +1 more source

Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants.

Proceedings of the National Academy of Sciences of the United States of America, 1971
R. Okazaki, M. Arisawa, A. Sugino
semanticscholar   +1 more source