Results 251 to 260 of about 1,611,597 (332)

Real-time imaging of rotation during synthesis by the replisome. [PDF]

Sci Adv
Retzer TM, Rajappa LT, Takahashi M, Hamdan SM, Duderstadt KE.   +4 more
europepmc   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Structural basis of the phosphoramidate N-benzimidazole group's influence on modified primer extension efficiency by Taq DNA polymerase. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Berdugin AA, Golyshev VM, Lomzov AA.
europepmc   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Decoupling Dynamics and Crosslink Stability in Supramolecular Hydrogels Using Associative Exchange

Advanced Materials, EarlyView.
How does reorganization impact the stability of supramolecular hydrogels? In contrast to dissociative crosslink exchange, implementing associative exchange in macroscale DNA hydrogels enables decoupling of reorganization dynamics from thermal and mechanical stability.
Pierre Le Bourdonnec, Charafeddine Ferkous, Léo Comunale, Luca Cipelletti, Rémi Merindol   +4 more
wiley   +1 more source

Cockayne syndrome mutation in XPG activate the integrated stress response. [PDF]

Hum Genet
Zhang D, Hartmann M, Cao Z, Zhu G, Najjar G, Günes C, Emmert S, Scharffetter-Kochanek K, Iben S.   +8 more
europepmc   +1 more source

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

π-π Stacking Determines the Selectivity of Unnatural DNA Base Pairs Even without Polymerase. [PDF]

ACS Phys Chem Au
Noori Z, Bermejo A, Bofill JM, Poater J.
europepmc   +1 more source

Label‐Free Sensing of Coronaviral Sequences via Kretschmann‐Configuration Reflectance Spectroscopic Ellipsometry: Sensitivity, Specificity, and Interfacial Effects

Advanced Materials Interfaces, EarlyView.
Spectroscopic ellipsometry in the Kretschmann‐Raether configuration (KRSE) is employed to characterize a DNA‐functionalized platform for viral sequence recognition. By merging SE with surface plasmon resonance, KRSE outperforms conventional SE, achieving nanomolar targeting through resonance wavelength shifts (δλ) measurements. Its enhanced interfacial
Silvia Maria Cristina Rotondi, Paolo Canepa, Francesco Bisio, Ornella Cavalleri, Maurizio Canepa   +4 more
wiley   +1 more source

An Optimized PCR Assay to Detect <i>Escherichia Coli</i> Harboring the <i>astA</i> Gene Encoding the Enteroaggregative <i>E. coli</i> Heat-Stable Enterotoxin 1 in Various Food Matrices. [PDF]

Food Saf (Tokyo)
Arai S, Ikeda N, Kadoguchi M, Arikawa E, Mizokoshi A, Shimmen K, Yokoyama K, Doi R, Saiki D, Yatsuyanagi J, Hirose S, Ohnishi T, Hara-Kudo Y.   +12 more
europepmc   +1 more source