Results 301 to 310 of about 1,611,597 (332)
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DNA polymerase switching: I. Replication factor C displaces DNA polymerase α prior to PCNA loading
Journal of Molecular Biology, 2000An important not yet fully understood event in DNA replication is the DNA polymerase (pol) switch from pol alpha to pol delta. Indirect evidence suggested that the clamp loader replication factor C (RF-C) plays an important role, since a replication competent protein complex containing pol alpha, pol delta and RF-C could perform pol switching in the ...
Maga G, Stucki M, Spadari S, Hubscher U
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DNA Polymerase β Inhibitors from Sandoricum koetjape
Journal of Natural Products, 1999Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase beta inhibition led to the isolation of three active compounds (1-3) having IC(50) values from 20 to 36 microM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase beta with IC(50) values ...
D A, Sun +3 more
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Molecular Modeling of RNA Polymerase II Mutations onto DNA Polymerase I
Journal of Molecular Biology, 1994Genetic and molecular analysis in Drosophila melanogaster identifies eight suppressor mutations in the second largest subunit of RNA polymerase II. The suppressor mutations fall into two classes: five are strong, result from the same serine to cysteine amino acid residue substitution and rescue one conditional lethal allele in the largest subunit of ...
W J, Kim, L P, Burke, M A, Mortin
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Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
Nature, 2020D. Ollis +5 more
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DNA-Dependent RNA Polymerase from Tetrahymena pyriformis
Canadian Journal of Biochemistry, 1972DNA-dependent RNA polymerase has been isolated from sonicated nuclei of the ciliate protozoan Tetrahymena pyriformis. The enzyme has been further purified by column chromatography on DEAE-Sephadex and is approximately 300-fold purified relative to total cellular protein.
S, Kurtz, R E, Pearlman
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An Induced Mitochondrial DNA Polymerase from Tetrahymena
European Journal of Biochemistry, 1972The activity of mitochondrial DNA polymerase from Tetrahymena pyriformis can be induced up to 50‐fold by several kinds of DNA damage (irradiation, thymine starvation etc.). The induced mitochondrial enzyme has been purified more than 5900‐fold based on whole treated cells.
O, Westergaard, B, Lindberg
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Crystal structure of Thermus aquaticus DNA polymerase
Nature, 1995The DNA polymerase from Thermus aquaticus (Taq polymerase), famous for its use in the polymerase chain reaction, is homologous to Escherichia coli DNA polymerase I (pol I) Like pol I, Taq polymerase has a domain at its amino terminus (residues 1-290) that has 5' nuclease activity and a domain at its carboxy terminus that catalyses the polymerase ...
Y, Kim +5 more
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Mechanistic Studies on DNA Polymerase I
1988The multifunctional DNA polymerase I (Pol I) of Escherichia coli has served as the most widely studied model for describing, at the molecular level, certain enzymatic processes involved in the replication of DNA (1). In addition to its polymerase activity, the enzyme also catalyzes DNA degradation by distinct 5′ → 3′and 3′ → 5′ exonuclease activities ...
V. Mizrahi +5 more
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Molecular Biotechnology, 2015
I. Oscorbin, U. Boyarskikh, M. Filipenko
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I. Oscorbin, U. Boyarskikh, M. Filipenko
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