Results 51 to 60 of about 1,611,597 (332)
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage [PDF]
, 2003 The molecular role of poly (ADP-ribose) polymerase-1 in DNA repair is unclear. Here, we show that the single-strand break repair protein XRCC1 is rapidly assembled into discrete nuclear foci after oxidative DNA damage at sites of poly (ADP-ribose ...
Caldecott, Keith W. +3 more
core +2 more sources
Template-switching during DNA synthesis byThermus aquaticusDNA polymerase I [PDF]
Nucleic Acids Research, 1995 Recombinant DNA molecules are often generated during the polymerase chain reaction (PCR) when partially homologous templates are available [e.g., see Pääbo et al. (1990) J. Biol. Chem. 265, 4718-4721]. It has been suggested that these recombinant molecules are a consequence of truncated extension products annealing to partially homologous templates on ...
S J, Odelberg +3 more
openaire +2 more sources
POLB Regulates Proliferation and Apoptosis of Bovine Primary Myocytes
AnimalsDNA polymerase β (DNA polymerase beta (POLB)) belongs to a member of the DNA polymerase X family, mainly involved in various biological metabolic processes, such as eukaryotic DNA replication, DNA damage repair, gene recombination, and cell cycle ...
Geyang Zhang +9 more
doaj +1 more source
Measurement of Epstein-Barr virus DNA load using a novel quantification standard containing two EBV DNA targets and SYBR Green I dye [PDF]
, 2016 BACKGROUND Reactivation of Epstein-Barr virus (EBV) infection may cause serious, life-threatening complications in immunocompromised individuals. EBV DNA is often detected in EBV-associated disease states, with viral load believed to be a reflection of ...
Ausimmune Investigator Group (AIG) +6 more
core +1 more source
Insects, 2022 Tungiasis is a neglected tropical disease caused by skin-penetrating female Tunga penetrans fleas. Although tungiasis causes severe health problems, its ecology is poorly understood and morphological descriptions of the larvae are unavailable.
Billy L. Amugune +6 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Biomolecules, 2020 Patients with advanced biliary tract cancer (BTC) inevitably experience progression after first-line, gemcitabine-based chemotherapy, due to chemo-resistance.
Yi-Ru Pan, Chiao-En Wu, Chun-Nan Yeh
doaj +1 more source
Biomolecules, 2022 Reactive oxygen species, generated as by-products of mitochondrial electron transport, can induce damage to mitochondrial DNA (mtDNA) and proteins. Here, we investigated whether the moderate accumulation of mtDNA damage in adult muscles resulted in ...
Mika Ozaki +2 more
doaj +1 more source
Phaeocystis globosa Virus DNA Polymerase X: a “Swiss Army knife”, Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair [PDF]
, 2011 Phaeocystis globosa virus 16T is a giant virus that belongs to the so-called nucleo-cytoplasmic large DNA virus (NCLDV) group. Its linear dsDNA genome contains an almost full complement of genes required to participate in viral base excision repair (BER).
Fernández-García, J.L. +3 more
core +4 more sources
Multiple DNA polymerases in Acinetobacter calcoaceticus
FEBS Letters, 1974 The synthesis of DNA is thought to be catalyzed by deoxynucleotide polymerizing enzymes. In the case of procariotic organisms it has recently been shown that E. coli and Bacillus subtilis possess three different DNA polymerases termed I, II and III [l-5]. DNA polymerase I from E. coli was the first enzyme to be characterized and its mechanism of action
Nes, Ingolf F., Kleppe, Kjell
openaire +2 more sources