Results 211 to 220 of about 576,294 (269)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Visualizing DNA repair factor recruitment at sites of transcription in single cells. [PDF]

Chromosome Res
Guan T, Shi Y, Lee TH, Oberdoerffer P.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network. [PDF]

Cell Death Dis
Qian R, Zhao Z, Sun X, Xin B, An P, Yang T, Wu N, Hu X, Wan Y.   +8 more
europepmc   +1 more source

Transferrin-modified liposomes enhance chemosensitivity in hepatocellular carcinoma by suppressing RDM1-mediated DNA repair. [PDF]

Front Oncol
Cai X, Wang X, Zhang Q, Gao F, Xu S, Lyu W, Ye J, Liu F, Zhang L.   +8 more
europepmc   +1 more source

DNA repair under heat: DNA polymerase λ modulates heat stress-induced mutagenesis in plants. [PDF]

Plant Cell
Wootan CM, Lutterman J, Springer N, Xu X, Zhang F.   +4 more
europepmc   +1 more source

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease

McHugh P, Roddan R, Schaich M, Nathan W, Kis I, Pierangelini A, Henderson L, Wee Rv, Martin L, El-Sagheer A, Kukura P, Brown T, O’Brien D, Newman J, iii DW, Schofield C, Houten B.   +16 more
europepmc   +1 more source

HSF1 and YTHDC1 enhance DNA repair under heat stress by promoting repair-associated gene expression. [PDF]

Nucleic Acids Res
Ding W, Deng Q, Wang T, Liu R, Xiang Y, Huang L, Liu J.   +6 more
europepmc   +1 more source

Early life exposure to N-nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice. [PDF]

Nat Commun
Volk LB, Norales M, Karjane C, Corrigan JJ, Alcaraz AJ, Pribyl LJ, Bugher NA, Blawas M, Dulski I, Arunachalam E, Gubina N, Michelsen E, Pichappan K, Yakimchuk N, Swanson M, Ma D, Levine SS, Plata DL, Croy RG, Samson LD, Essigmann JM, Yauk CL, Carrasco SE, Engelward BP.   +23 more
europepmc   +1 more source

Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition. [PDF]

Cancer Res
Sottnik JL, Shackleford MT, Nesiba CS, Richer AL, Fleischmann Z, Swartz JM, Rowland CE, Musick M, Fu R, Myler LR, Opresko PL, Mehrotra S, Sokol ES, Hesselberth JR, Diamond JR, Sikora MJ.   +15 more
europepmc   +1 more source