Results 231 to 240 of about 1,028,456 (338)

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Characteristics of Germline and Somatic Mutations of DNA Repair Genes in Korean Men with Prostate Cancer. [PDF]

World J Mens Health
Lee H, Ho JN, Song SH, Oh JJ, Huh JS, Kim HM, Kim KH, Kim S, Byun SS.   +8 more
europepmc   +1 more source

Evaluation of DNA Mismatch Repair Proteins by Immunohistochemistry Using Two Antibodies

Leonardo S. Lino-Silvca, Mariana Salazar-Castillo, Scarlett F. Balderas-López, Sabrina B. Martínez-Villavicencio, Luisa F. Rivera-Moncada, Hanna I Ortega-Martínez, César Zepeda‐Najar   +6 more
openalex   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Enhancing cancer susceptibility to disulfidptosis by inducing cell cycle arrest and impairing DNA repair. [PDF]

Theranostics
Lin J, Yang X, Jiang C, Liu X, Shi J.
europepmc   +1 more source

Studies on the interaction of the inhibitor of apoptosis protein Survivin with DNA-dependent protein kinase to modulate DNA double-strand break repair

, 2018
Fabian Weipert
openalex   +2 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer. [PDF]

Mol Med
Danesova N, Horak J, Valickova A, Gil-Korilis A, Ergui-Arbizu J, Palek R, Bruha J, Levy M, Skrobanek P, Kral J, Jungwirth J, Neuzil J, Vymetalkova V, Vodicka P, Vodenkova S, Tomasova K.   +15 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction. [PDF]

Nat Commun
Vázquez García C, Obermayer B, Keller B, Lebedin M, Ratswohl C, Abolhassani H, Busse A, Di Virgilio M, Mathas S, Speiser D, Beule D, Pan-Hammarström Q, Warnatz K, de la Rosa K.   +13 more
europepmc   +1 more source