Results 231 to 240 of about 3,725,761 (393)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Regulation of DNA repair gene expression by PRMT5. [PDF]

MicroPubl Biol
Bliss H, Bouley RA, Petreaca RC.
europepmc   +1 more source

Binding of a Nitroxyl to Radiation-induced DNA Transients in Repair and Repair Deficient of E. coli K-12. [PDF]

, 1975
Einar Wold, Tor Brustad, E. Kulonen, Juhani Jänne, Synnøve Liaaen‐Jensen   +4 more
openalex   +1 more source

Exploring potent miRNA combinations for detecting early-stage breast cancer

Molecular Therapy: Nucleic Acids
Breast cancer (BC) is the most prevalent cancer among women globally. Identifying BC at its early stage is of significant importance; however, due to the limited resolution and the accompanying adverse events of the current detection methods, including ...
Barbara N. Borsos, Zoltán G. Páhi, Tibor Pankotai   +2 more
doaj  

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

DNA repair and the contribution to chemotherapy resistance. [PDF]

Genome Med
Nesic K, Parker P, Swisher EM, Krais JJ.
europepmc   +1 more source

Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage lambda.

, 1978
J B Hays, S Boehmer
openalex   +1 more source

Molecular recombination and the repair of DNA double-strand breaks in CHO cells [PDF]

, 1979
Michael A. Resnick, Peter D. Moore
openalex   +1 more source

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Proceedings of the National Academy of Sciences of the United States of America, 2018
Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, D. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, J. O’Connell, Beverly A. Baptiste, T. Stevnsner, M. Mattson, V. Bohr   +12 more
semanticscholar   +1 more source