Results 171 to 180 of about 82,738 (226)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Chromosome-scale genome assembly of the European common cuttlefish <i>Sepia officinalis</i>. [PDF]

Elife
Rencken SD, Tushev G, Hain D, Ciirdaeva E, Simakov O, Laurent G.   +5 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

From Mutation to Manifestation: Penetrance in Amyotrophic Lateral Sclerosis. [PDF]

Genes (Basel)
Richard E, Al-Hajj Vourc'h S, Marouillat S, Beltran S, Blasco H, Corcia P, Vourc'h P.   +6 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Losing genes, gaining edits: how relaxed selection and inverted repeat expansion shape RNA editing in Schizaeaceae plastomes. [PDF]

Plant J
Fauskee BD, Kuo LY, Kwok van der Giezen F, Pryer KM.   +3 more
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. [PDF]

Nat Commun
Collotta G, Gatti M, Ungureanu IM, van Ackeren V, Rannou E, Vivalda F, Gomez Vieito D, Fishwick KM, von Aesch C, Porro A, Ungerleider K, Heidari A, Guérois R, Harding RJ, Bischof S, Balmus G, Sartori AA.   +16 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Transcriptional capacity limits copper resistance in yeast harboring highly expanded <i>CUP1</i> arrays. [PDF]

MicroPubl Biol
Takesue H, Okada S, Ito T.
europepmc   +1 more source