Results 331 to 340 of about 3,738,521 (387)

HU promotes higher order chromosome organization and influences DNA replication rates in Streptococcus pneumoniae. [PDF]

Nucleic Acids Res
Mazzuoli MV, van Raaphorst R, Martin LS, Bock FP, Thierry A, Marbouty M, Waclawiková B, Stinenbosch J, Koszul R, Veening JW.   +9 more
europepmc   +1 more source

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source

Cold Atmospheric Plasma Selectively Disrupts Breast Cancer Growth in a Bioprinted 3D Tumor‐Stroma Co‐Culture Model

Advanced Healthcare Materials, EarlyView.
This research introduces a cold plasma‐based platform for treating breast cancer bone metastases. Using a novel bioprinted 3D tumor‐stroma model, it highlights the selective antitumor effects of plasma‐generated reactive species. The platform aims to advance non‐invasive therapeutic strategies, offering potential clinical applications in controlling ...
Laura M. Bouret, Jean‐Baptiste Billeau, Michael H. Weber, Derek H. Rosenzweig, Stephan Reuter   +4 more
wiley   +1 more source

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Understanding DNA replication and replication stress as avenues to combat cancer. [PDF]

Commun Biol
Naim V.
europepmc   +1 more source

Roles for the 3D genome in the cell cycle, DNA replication, and double strand break repair. [PDF]

Front Cell Dev Biol
Giles KA, Taberlay PC, Cesare AJ, Jones MJK.   +3 more
europepmc   +1 more source

Supervised and unsupervised deep learning-based approaches for studying DNA replication spatiotemporal dynamics. [PDF]

Commun Biol
Ng-Kee-Kwong J, Philps B, Smith FNC, Sobieska A, Chen N, Alabert C, Bilen H, Buonomo SCB.   +7 more
europepmc   +1 more source

Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate. [PDF]

Genes Dev
Franklin R, Zhang B, Frazier J, Chen M, Do BT, Padayao S, Wu K, Vander Heiden MG, Vakoc CR, Roe JS, Ninova M, Murn J, Sykes DB, Cheloufi S.   +13 more
europepmc   +1 more source

The characterisation of the complete mitochondrial genome of Polygonatum Kingianum reveals recombination mediated by repeats associated with DNA replication. [PDF]

Sci Rep
Tao A, Tao J, Gan Z, Zhang Y, Yin C, Jiang G.   +5 more
europepmc   +1 more source

Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response. [PDF]

Cells
Malysa A, Zhang XM, Bepler G.
europepmc   +1 more source