Results 351 to 360 of about 3,738,521 (387)
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Fidelity of mammalian DNA replication and replicative DNA polymerases
Biochemistry, 1991Current models suggest that two or more DNA polymerases may be required for high-fidelity semiconservative DNA replication in eukaryotic cells. In the present study, we directly compare the fidelity of SV40 origin-dependent DNA replication in human cell extracts to the fidelity of mammalian DNA polymerases alpha, delta, and epsilon using lacZ alpha of ...
Ralph D. Sabatino +8 more
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Annual Review of Biochemistry, 1986
ADENOVIRUS 736 Genome Structure and Replication Mode 736 In Vitro Replication 736 SV40 DNA REPLICATION 739 The Role ofT Antigen in Initiation . 740 DNA Sequences Required for Replication 742 In Vitro Replication Systems 744 Proteins Required/or SV40 DNA Replication In Vitro 745 DNA Sequences Required 746 Minimal Origins Used In Vitro
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ADENOVIRUS 736 Genome Structure and Replication Mode 736 In Vitro Replication 736 SV40 DNA REPLICATION 739 The Role ofT Antigen in Initiation . 740 DNA Sequences Required for Replication 742 In Vitro Replication Systems 744 Proteins Required/or SV40 DNA Replication In Vitro 745 DNA Sequences Required 746 Minimal Origins Used In Vitro
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Frontiers in Bioscience, 2004
The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM complex acts as a replicative helicase in eukaryotes.
Hideo Nishitani, Zoi Lygerou
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The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM complex acts as a replicative helicase in eukaryotes.
Hideo Nishitani, Zoi Lygerou
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DNA replication in thermophiles
Biochemical Society Transactions, 2004DNA replication enzymes in the thermophilic Archaea have previously attracted attention due to their obvious use in methods such as PCR. The proofreading ability of the Pyrococcus furiosus DNA polymerase has resulted in a commercially successful product (Pfu polymerase).
James P. J. Chong +2 more
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Annual Review of Biochemistry, 1992
PERSPECTIVES AND SUMMARY ..... 673 INTRODUCTION TO REPLICATION OPERATIONS 674 ELONGATION..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 677 The DNA Polymerase Complexes 677 Primosomes .. . .... . ... .. . ..... . ...... . . ...... ... . . . ....... ... . .....
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PERSPECTIVES AND SUMMARY ..... 673 INTRODUCTION TO REPLICATION OPERATIONS 674 ELONGATION..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . 677 The DNA Polymerase Complexes 677 Primosomes .. . .... . ... .. . ..... . ...... . . ...... ... . . . ....... ... . .....
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Annual Review of Genetics, 2014
DNA replication is essential for all life forms. Although the process is fundamentally conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic studies have demonstrated that the process and the proteins involved in ...
Lori M. Kelman, Z. Kelman
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DNA replication is essential for all life forms. Although the process is fundamentally conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic studies have demonstrated that the process and the proteins involved in ...
Lori M. Kelman, Z. Kelman
semanticscholar +1 more source
Papillomavirus DNA Replication
2003Papillomavirus genomes replicate and are maintained as stable extrachromosomal plasmid DNA (episomes) in many cell lines (reviewed in ref. 1). This process requires the viral E1 and E2 proteins and the origin of replication (2,3). The minimal origin of replication consists of an E1 binding site, an E2 binding site, and an AT rich region that probably ...
Maureen C. Ferran, Alison A. McBride
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On the mechanism of DNA replication
Journal of Theoretical Biology, 1965Abstract A mechanism of DNA replication is proposed which involves a bifunctional replicase enzyme. Evidence is cited indicating that the major groove of the DNA helix represents the site of its replication. Base pairing and synthesis of single strands is pictured as occurring simultaneously on opposing sides of the groove, thus involving bases which
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1986
We have explored various strategies for exploiting the yeast genetic and biochemical system for understanding DNA replication. Because of the long time that has intervened between the isolation of random replication mutants of yeast and the identification of the gene products affected, an alternative approach to elucidating the molecular basis of ...
Martin E. Budd +6 more
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We have explored various strategies for exploiting the yeast genetic and biochemical system for understanding DNA replication. Because of the long time that has intervened between the isolation of random replication mutants of yeast and the identification of the gene products affected, an alternative approach to elucidating the molecular basis of ...
Martin E. Budd +6 more
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Current Opinion in Genetics & Development, 2002
The study of DNA replication in eukaryotic chromosomes has revealed a multitude of different regulatory levels. Nuclear and chromosomal location as well as chromatin structure may affect the activity of replication origins and their modulation during development.
Anja Katrin Bielinsky, Susan A. Gerbi
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The study of DNA replication in eukaryotic chromosomes has revealed a multitude of different regulatory levels. Nuclear and chromosomal location as well as chromatin structure may affect the activity of replication origins and their modulation during development.
Anja Katrin Bielinsky, Susan A. Gerbi
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