Results 151 to 160 of about 4,499,395 (250)

Decoupling of Bypass Efficiency and Mutagenicity of the 2-Acetylaminofluorene C8-Guanine Adduct by DNA Sequence Context. [PDF]

Toxics
Chen YT, Qi R, Ma J, Cai A, Cho BP, Li D.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Two of a Kind: Composition and Photophysics of Two Silver Nanoclusters Stabilized by the Same DNA Sequence. [PDF]

J Am Chem Soc
Liccardo L, Kanazawa H, Romolini G, Cerretani C, Lind SW, Polido B, Mollerup CB, Rück V, Huang Z, Lo Leggio L, Kondo J, Vosch T.   +11 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory. [PDF]

Science
Cowley CJ, Sajjath SM, Soto-Ugaldi LF, Steiger M, Larsen SB, Carroll T, Barrows D, Mattei A, Gonzales KAU, Wang W, Li K, Meissner A, Kretzmer H, Pe'er D, Fuchs E.   +14 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A novel relationship between time offsets in capillary electrophoresis and DNA sequence variations in short tandem repeats. [PDF]

J Forensic Sci
Johnson D, Curran J, Kalafut T.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

From randomness to recognition: modeling the evolution of DNA sequence information during enrichment for binding. [PDF]

Bioinform Adv
Maher V, Martin D, Spetzler D, Zhao ZG, O'Neill H, Woodbury NW.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source