Results 81 to 90 of about 2,635,192 (296)

Photoelectrochemical Detection of Dengue-Related Oligonucleotide Sequence Using Anthocyanin as an Intercalating Agent and Electrochromic Material [PDF]

, 2010
World Health Organization (WHO) presupposes a confirmation of dengue virus infection diagnosis with two criteria, i.e. clinical and laboratory criteria.
Ibrahim, A. S. (Anwar), Kusmardi, K. (Kusmardi), Tedjo, A. (Aryo)   +2 more
core  

A p-Adic Model of DNA Sequence and Genetic Code

, 2006
Using basic properties of p-adic numbers, we consider a simple new approach to describe main aspects of DNA sequence and genetic code. Central role in our investigation plays an ultrametric p-adic information space which basic elements are nucleotides ...
A. Khrennikov, A. Khrennikov, A. Yu. Dragovich, A. Yu. Khrennikov, B. Dragovich, F. Q. Gouvea, J. D. Watson, L. Brekke, L. Frappat, L. Frappat, R. Rammal, S.V. Kozyrev, V. A. Avetisov, V. A. Avetisov, V. A. Avetisov, V. S. Vladimirov   +15 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Nucleosome DNA sequence structure of isochores

BMC Genomics, 2011
Background Significant differences in G+C content between different isochore types suggest that the nucleosome positioning patterns in DNA of the isochores should be different as well. Results Extraction of the patterns from the isochore DNA sequences by
Trifonov Edward N, Bettecken Thomas, Frenkel Zakharia M   +2 more
doaj   +1 more source

Structure, stability and elasticity of DNA nanotube

, 2014
DNA nanotubes are tubular structures composed of DNA crossover molecules. We present a bottom up approach for construction and characterization of these structures. Various possible topologies of nanotubes are constructed such as 6-helix, 8-helix and tri-
Dwaraknath, Anjan, Joshi, Himanshu, Maiti, Prabal K.   +2 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The future of DNA sequence archiving

GigaScience, 2012
Archives operating under the International Nucleotide Sequence Database Collaboration currently preserve all submitted sequences equally, but rapid increases in the rate of global sequence production will soon require differentiated treatment of DNA ...
Cochrane Guy, Cook Charles E, Birney Ewan   +2 more
doaj   +1 more source

Mapping the Space of Genomic Signatures

, 2014
We propose a computational method to measure and visualize interrelationships among any number of DNA sequences allowing, for example, the examination of hundreds or thousands of complete mitochondrial genomes.
Bryans, Nathaniel, Dattani, Nikesh S., Davis, Katelyn, Hill, Kathleen A., Karamichalis, Rallis, Kari, Lila, Sayem, Abu S.   +6 more
core   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source