Results 151 to 160 of about 3,598,749 (292)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

sedimix: a workflow for the analysis of hominin nuclear DNA sequences from sediments. [PDF]

Bioinformatics
Xu J, Zavala EI, Moorjani P.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Genetic Variation and Demographic History of Green Weevil <i>Hypomeces pulviger</i> (Herbst, 1795) (Coleoptera: Curculionidae) in Thailand Examined by Mitochondrial DNA Sequences. [PDF]

Biology (Basel)
Pradit N, Pilap W, Jaroenchaiwattanachote C, Saijuntha J, Tawong W, Kongbuntad W, Laotongsan P, Wongpakam K, Inkhavilay K, Thanee I, Saijuntha W, Tantrawatpan C.   +11 more
europepmc   +1 more source

Banking DNA sequences [PDF]

Nature, 1980
openaire   +2 more sources

Sequencing of Genomic DNA [PDF]

BioTechniques, 1999
Ulrich Mahlknecht, Dieter Hoelzer, Richard Bucala   +2 more
openaire   +3 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Ensemble Deep Learning Models on Raw DNA Sequences for Viral Genome Identification in Human Samples. [PDF]

Sensors (Basel)
De Nat M, Boscolo S, Gallo SP, Nanni L, Fusaro D.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

CT-TADB predicts TAD boundaries without Hi-C by integrating DNA sequences and epigenomic features. [PDF]

NPJ Syst Biol Appl
Chen T, Wang S, Jin Y, Yuan Y, Liang Z, Shen Y.   +5 more
europepmc   +1 more source