Results 21 to 30 of about 6,016,549 (343)
Priming the Engine of DNA Synthesis [PDF]
Structure, 2012 In this issue of Structure, Rymer and colleagues present the first crystal structures of a bacterial DnaG primase with bound substrate NTPs and alarmone inhibitors. A thoughtful comparative structural analysis provides important insights into the chemical mechanism of primase.
Mansfield, Robyn E, Dixon, Nicholas E
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Definitions, 2020 DNA Synthesis Rescue involves resumption of DNA synthesis, polymeric linkage of deoxyribonucleotides by phosphate linkage, following arrest of DNA synthesis due to DNA damage. One rescue mechanism involves activation of proteins involved in DNA repair.
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Taxonomic and chemical assessment of exceptionally abundant rock mine biofilm [PDF]
PeerJ, 2017 Background An exceptionally thick biofilm covers walls of ancient gold and arsenic Złoty Stok mine (Poland) in the apparent absence of organic sources of energy.
Karolina Tomczyk-Żak +3 more
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Synthesis and Properties of Isobicyclo‐DNA [PDF]
Chemistry – A European Journal, 2013 AbstractWe present the synthesis of the isobicyclo‐DNA building blocks with the nucleobases A, C, G and T, as well as biophysical and biological properties of oligonucleotides derived thereof. The synthesis of the sugar part was achieved in 5 steps starting from a known intermediate of the tricyclo‐DNA synthesis. Dodecamers containing single isobicyclo‐
Anna-Barbara Gerber +1 more
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Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. [PDF]
PLoS Pathogens, 2010 Modulation of host DNA synthesis is essential for many viruses to establish productive infections and contributes to viral diseases. Human cytomegalovirus (HCMV), a large DNA virus, blocks host DNA synthesis and deregulates cell cycle progression.
Zhikang Qian +4 more
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Nostoc edaphicum CCNP1411 from the Baltic Sea—A New Producer of Nostocyclopeptides
Marine Drugs, 2020 Nostocyclopeptides (Ncps) constitute a small class of nonribosomal peptides, exclusively produced by cyanobacteria of the genus Nostoc. The peptides inhibit the organic anion transporters, OATP1B3 and OATP1B1, and prevent the transport of the toxic ...
Anna Fidor +5 more
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Terminator-free template-independent enzymatic DNA synthesis for digital information storage
Nature Communications, 2019 DNA is an emerging medium for digital data and its adoption can be accelerated by synthesis processes specialized for storage applications. Here, we describe a de novo enzymatic synthesis strategy designed for data storage which harnesses the template ...
Henry H. Lee +4 more
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MicrobiologyOpen, 2019 This study provides a deep modern insight into the phylogenetic diversity among bacterial consortia found in working and nonworking high‐methane natural gas pipelines located in Poland.
Agnieszka Staniszewska +6 more
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Large-scale de novo DNA synthesis: technologies and applications
Nature Methods, 2014 For over 60 years, the synthetic production of new DNA sequences has helped researchers understand and engineer biology. Here we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on recent technologies that allow ...
Sriram Kosuri, G. Church
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DNA Synthesis at a Fork in the Presence of DNA Helicases [PDF]
European Journal of Biochemistry, 1982 In a mixture of Escherichia coli DNA polymerase III holoenzyme, single‐strand‐binding protein, artificially forked λ bacteriophage DNA with primer annealed to the leading side of the fork, dNTPs and ATP, DNA synthesis is enhanced by helicaseII, less so by helicases I, III or rep protein of E. coli or T4 phage helicase. The effect of helicase II depends
Kuhn, B., Abdel‐Monem, M.
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