Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]
, 2010 Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G +5 more
core +2 more sources
DNA display III. Solid-phase organic synthesis on unprotected DNA. [PDF]
PLoS Biology, 2004 DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate utility, however, hinges upon the diversity of chemical reactions that can be executed in the presence of unprotected DNA.
David R Halpin +3 more
doaj +1 more source
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]
, 2014 DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ +13 more
core +1 more source
New Methods for Synthesizing DNA, RNA, and Phosphonates
CHIMIA, 2005 The development of new methods for the synthesis of DNA, RNA, and phosphonates has enabled new applications in biochemistry and biology.
Marvin H. Caruthers
doaj +1 more source
Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia [PDF]
, 2006 Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in
Brown +15 more
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Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates [PDF]
, 2013 Nonhomologous end-joining (NHEJ) pathways repair DNA double-strand breaks (DSBs) in eukaryotes and many prokaryotes, although it is not reported to operate in the third domain of life, archaea. Here, we describe a complete NHEJ complex, consisting of DNA
Bartlett, Edward +2 more
core +1 more source
Synthetic biology—putting engineering into biology [PDF]
, 2006 Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core +1 more source
Evidence for the appearance of novel gene products during amphibian blastulation [PDF]
, 1968 Genetic information begins to be transcribed during early cleavage in amphibian embryos,(1,2) and the tempo of informational RNA synthesis increases gradually through cleavage and into the early blastula stage. Previous studies from this laboratory (3,4)
Crippa, Marco +2 more
core +2 more sources
Genome-wide identification of essential genes in the invasive Streptococcus anginosus strain
Scientific ReportsStreptococcus anginosus, part of the Streptococcus anginosus group (SAG), is a human commensal increasingly recognized as an opportunistic pathogen responsible for abscesses formation and infections, also invasive ones.
Aleksandra Kuryłek +4 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Over the past decades, remarkable progress on phosphoramidite chemistry-based large-scale de novo oligonucleotide synthesis has been achieved, enabling numerous novel and exciting applications.
Li-Fu Song +8 more
doaj +1 more source