Results 81 to 90 of about 16,951 (259)

Supercoiled DNA: Structure [PDF]

, 2015
Supercoiling is introduced into DNA molecules when the double helix is twisted around its own axis in three‐dimensional space. Experimental techniques that are sensitive to molecular shape can be used to analyse the topological states of DNA, but the ...
Bowater, Richard
core   +1 more source

Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms [PDF]

Structure, 2008
DNA topoisomerases resolve DNA topological problems created during transcription, replication, and recombination. These ubiquitous enzymes are essential for cell viability and are highly potent targets for the development of antibacterial and antitumoral drugs.
Graille, Marc, Cladière, Lionel, Durand, Dominique, Lecointe, François, Gadelle, Danièle, Quevillon-Cheruel, Sophie, Vachette, Patrice, Forterre, Patrick, van Tilbeurgh, Herman   +8 more
openaire   +2 more sources

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives

E-Journal of Chemistry, 2011
Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV.
Eskandar Alipour, Negar Mohammad Hosseini, Fatemeh Panah, Sussan K. Ardestani, Maliheh Safavi, Abbas Shafiee, Alireza Foroumadi   +6 more
doaj   +1 more source

Mutations in topoisomerase IIβ result in a B cell immunodeficiency. [PDF]

, 2019
B cell development is a highly regulated process involving multiple differentiation steps, yet many details regarding this pathway remain unknown. Sequencing of patients with B cell-restricted immunodeficiency reveals autosomal dominant mutations in ...
Austin, Caroline A, Booshehri, Laela M, Broderick, Lori, Brydges, Susannah D, Cowell, Ian G, Croker, Ben A, Frazer, Kelly A, Gebauer, Corinna, Guaderrama, Marisela, Hakonarson, Hakon, Harr, Margaret, Hoffman, Hal M, Hügle, Boris, Kucharova, Karolina, Li, Dong, McGeough, Matthew D, Patel, Niraj C, Putnam, Christopher D, Wang, Jian, Xu, Xun, Yost, Shawn, Zackai, Elaine, Zhang, Jianguo   +22 more
core  

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control

Vaccines, 2020
African swine fever (ASF) is, once more, spreading throughout the world. After its recent reintroduction in Georgia, it quickly reached many neighboring countries in Eastern Europe.
João Coelho, Alexandre Leitão
doaj   +1 more source

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals [PDF]

, 2016
DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain.
Ahmad, Muzammil, Ciaramella, Maria, Debat, Hélène, Gorospe, Myriam, Hsieh, Tao-Shih, Lee, Seung Kyu, Leng, Fenfei, Li, Wen, Martindale, Jennifer L, Nadal, Marc, Niu, Hengyao, Pommier, Yves, Shen, Weiping, Siaw, Grace Ee-Lu, Tse-Dinh, Yuk-Ching, Wang, Quan, Wang, weidong, Xu, Dongyi, Xu, Yutong, Zhang, Hongliang, Zou, Sige   +20 more
core   +3 more sources

Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.

PLoS ONE, 2007
The 2.7 A crystal structure of the 55-kDa N-terminal breakage-reunion domain of topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the quinolone targets from a gram-positive bacterium, has been solved and reveals a ...
Ivan Laponogov, Dennis A Veselkov, Maninder K Sohi, Xiao-Su Pan, Aniruddha Achari, Cheng Yang, Joseph D Ferrara, L Mark Fisher, Mark R Sanderson   +8 more
doaj   +1 more source

Knotting probabilities after a local strand passage in unknotted self-avoiding polygons

, 2011
We investigate the knotting probability after a local strand passage is performed in an unknotted self-avoiding polygon on the simple cubic lattice.
Bates A, Berg B, Berger J M, Berretti A, Buck G, Burnier Y, C E Soteros, Clisby N, de Carvalho C A, de Carvalho C A, Fishman G S, Fogg J M, Gelman A, Gelman A, Guttmann A J, Hua X, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Liu Z, Liu Z, Liu Z, Liu Z R, M L Szafron, Manturov V, Marcone B, Orlandini E, Orlandini E, Orlandini E, Rybenkov V V, Shaw S Y, Sokal A D, Sumners D W, Szafron M L, Szafron M L, Trigueros S, Vologodskii A, Yan J   +38 more
core   +1 more source