Results 21 to 30 of about 1,893,739 (263)

Shield strike shatter in DNA topology and nuclease interactions [PDF]

Nature Communications
DNA degradation by nucleases is central to genome maintenance, immune defense, and the clearance of extracellular DNA, yet its execution at the single-molecule level remains poorly defined.
Jingge Yang, Yujia Qiu, Keesiang Lim, Toshio Ando, Richard W. Wong   +4 more
doaj   +2 more sources

Editorial: Chromosome architecture and DNA topology in prokaryotes [PDF]

Frontiers in Microbiology, 2023
Tamara Basta, Estelle Crozat, Ian Grainge   +2 more
doaj   +2 more sources

Pamoic acid and carbenoxolone specifically inhibit CRISPR/Cas9 in bacteria, mammalian cells, and mice in a DNA topology-specific manner [PDF]

Genome Biology
Background Regulation of the target DNA cleavage activity of CRISPR/Cas has naturally evolved in a few bacteria or bacteriophages but is lacking in higher species.
Yuxuan Zhang, Wentao Zou, Yueyang Zhou, Jiaqi Chen, Youtian Hu, Fang Wu   +5 more
doaj   +2 more sources

Rational design of topology-defined DNA nanoframeworks for antigen delivery and cross-presentation [PDF]

Journal of Nanobiotechnology
DNA nanoframeworks (DNFs) provide structurally programmable platforms for antigen delivery, yet how framework topology influences antigen cross-presentation remains unclear.
Ying Cao, Yuanyuan Wu, Xian Huang, Kui Huang, Tomasz Maj, Zhao Xu, Jingwei Sun, Qian Shi, Yang Yang   +8 more
doaj   +2 more sources

Regulation of DNA Topology in Archaea: State of the Art and Perspectives [PDF]

Molecular Microbiology
Tamara Basta
exaly   +2 more sources

A review on nonlinear DNA physics [PDF]

Royal Society Open Science, 2020
The study and the investigation of structural and dynamical properties of complex systems have attracted considerable interest among scientists in general and physicists and biologists in particular.
Dalibor Chevizovich, Davide Michieletto, Alain Mvogo, Farit Zakiryanov, Slobodan Zdravković   +4 more
doaj   +1 more source

DNA topology and transcription. [PDF]

Nucleus, 2014
Chromatin is a complex assembly that compacts DNA inside the nucleus while providing the necessary level of accessibility to regulatory factors conscripted by cellular signaling systems. In this superstructure, DNA is the subject of mechanical forces applied by variety of molecular motors.
Kouzine F, Levens D, Baranello L.
europepmc   +4 more sources

Data of transcriptional effects of the merbarone-mediated inhibition of TOP2

Data in Brief, 2022
Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands.
Fernando M. Delgado-Chaves, Pedro Manuel Martínez-García, Andrés Herrero-Ruiz, Francisco Gómez-Vela, Federico Divina, Silvia Jimeno-González, Felipe Cortés-Ledesma   +6 more
doaj   +1 more source

Distinguishing regional from within-codon rate heterogeneity in DNA sequence alignments [PDF]

, 2009
We present an improved phylogenetic factorial hidden Markov model (FHMM) for detecting two types of mosaic structures in DNA sequence alignments, related to (1) recombination and (2) rate heterogeneity.
Husmeier, D., Mantzaris, Alexander Vassilios, Dirk Husmeier, Mantzaris, A.V., Alexander V. Mantzaris   +4 more
core   +5 more sources

Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays [PDF]

Journal of Biological Chemistry, 2019
Victor B Zhurkin, Sergei A Grigoryev, Davood Norouzi   +2 more
exaly   +2 more sources