Results 51 to 60 of about 1,893,739 (263)
Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage [PDF]
, 2006 Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CLaction in the presence of topoisomerase IV from Streptococcus pneumoniae.
Fisher, LM +11 more
core +1 more source
Structural basis for allosteric regulation of Human Topoisomerase IIα
Nature Communications, 2021 Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing ...
Arnaud Vanden Broeck +5 more
doaj +1 more source
Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. [PDF]
Sci Rep, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Gu M +5 more
europepmc +2 more sources
DNA topology: Topological transformation of DNA by reaction of cisplatin-DNA-core histone complexes with human DNA topoisomerase [PDF]
Nucleic Acids Symposium Series, 2002 Cis-diamminedichloroplatinium(II), an active antitumor agent binds to core-histone -SV40 DNA complexes prepared by reaction of DNA with core-histone, and alters the fiber-like structure into the loosened structure. In order to model the cisplatin-modified chromatin complexes in cell, the complexes were reacted with human DNA topo II.
Shigeki, Kobayashi +4 more
openaire +2 more sources
Archaea: A Gold Mine for Topoisomerase Diversity
Frontiers in Microbiology, 2021 The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the ...
Florence Garnier +6 more
doaj +1 more source
DNA topology and topoisomerases [PDF]
Biochemistry and Molecular Biology Education, 2009 AbstractDNA is essentially an extremely long double‐stranded rope in which the two strands are wound about one another. As a result, topological properties of the genetic material, including DNA underwinding and overwinding, knotting, and tangling profoundly influence virtually every major nucleic acid process.
Joseph E, Deweese +2 more
openaire +2 more sources
Physical Characterization of Gemini Surfactant-Based Synthetic Vectors for the Delivery of Linear Covalently Closed (LCC) DNA Ministrings. [PDF]
PLoS ONE, 2015 In combination with novel linear covalently closed (LCC) DNA minivectors, referred to as DNA ministrings, a gemini surfactant-based synthetic vector for gene delivery has been shown to exhibit enhanced delivery and bioavailability while offering a ...
Chi Hong Sum +3 more
doaj +1 more source
Applications of topology to DNA [PDF]
Banach Center Publications, 1998 0. Some preliminaries. Many biological processes affect topological properties of DNA. Duplex DNA consists of two backbone strands wound about each other in a righthanded helical fashion. Each strand consists of a sugar phosphate backbone with a nitrogenous base attached to each sugar. The four possible bases are adenine (A), guanine (G), cytosine (C),
De Sumners, Isabel Darcy
openaire +1 more source
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
Nature Communications, 2020 Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.
John Fielden +16 more
doaj +1 more source
Topology change and context dependence [PDF]
, 1999 The nonclassical features of quantum mechanics are reproduced using models constructed with a classical theory-general relativity. The inability to define complete initial data consistently and independently of future measurements, nonlocality, and the ...
Hadley, Mark J.
core +1 more source