Results 161 to 170 of about 119,528 (240)
AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective
Advanced Intelligent Discovery, EarlyView.The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley +1 more source
Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA
Angewandte Chemie, EarlyView.The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio +7 more
wiley +2 more sources
Correction to 'TORCphysics: a physical model of DNA-topology-controlled gene expression'. [PDF]
Nucleic Acids Reseuropepmc +1 more source
Tethered Particle Motion: An Easy Technique for Probing DNA Topology and Interactions with Transcription Factors. [PDF]
Methods Mol Biol, 2018 Kovari DT, Yan Y, Finzi L, Dunlap D.
europepmc +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.SuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Yahongyang Lydia Li +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters +15 more
wiley +2 more sources
Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology. [PDF]
Mol Oncol, 2019 Ahmed SM, Dröge P.
europepmc +1 more source
American Journal of Botany, EarlyView.Abstract Premise Budding speciation occurs when peripheral populations adapt to local ecological conditions and “bud” off from a widespread progenitor species. Traditionally regarded as rare because of its sympatric and parapatric nature, budding speciation is largely understudied.
Eli J. Allen +3 more
wiley +1 more source
A Multi‐Stimuli Transformational Network of Benzil‐Based Pd(II) Assemblies
Angewandte Chemie, EarlyView.Incorporation of a flexible and chemically reactive benzil backbone into the ligand structure allows it to access multiple conformations, enabling the formation of diverse homo‐ and heteroleptic Pd(II) assemblies with different nuclearities and topologies.
Zhiwei Zeng +5 more
wiley +2 more sources
Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. [PDF]
Sci Rep, 2016 Gu M +5 more
europepmc +1 more source