Results 61 to 70 of about 1,893,739 (263)
On the viability of Escherichia coli cells lacking DNA topoisomerase I [PDF]
, 2012 Copyright @ 2012 Stockum et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution,
Lloyd, RG +8 more
core +1 more source
The topology of the kinetoplast DNA network
Cell, 1995 Kinetoplast DNA (kDNA) of trypanosomatid parasites is a network of approximately 5000 catenated DNA minicircles and approximately 25 maxicircles. We developed the following strategy to deduce the topological linkage of the minicircles of the Crithidia fasciculata network.
Chen, Junghuei +4 more
openaire +2 more sources
Methods for designing the next generation of aircraft architectures using topology optimisation [PDF]
, 2010 The need from energy efficient transportation has resulted in a growing interest in new aircraft configurations such as the Blended Wing Body. There is very little collective knowledge on the optimal structural layouts of these aircraft, and the ...
Eves, Jamie Samantha
core +6 more sources
Nucleosomal DNA has topological memory
Nature CommunicationsOne elusive aspect of the chromosome architecture is how it constrains the DNA topology. Nucleosomes stabilise negative DNA supercoils by restraining a DNA linking number difference (∆Lk) of about −1.26.
Joana Segura +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA [PDF]
, 2011 <b>Background</b> Type II DNA topoisomerases are essential, ubiquitous enzymes that act to relieve topological problems arising in DNA from normal cellular activity.
Caroline A. Austin +7 more
core +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
On the Topology Characterization of Guifi.net [PDF]
, 2012 In this paper it is analyzed the topology of Guifi.net Wireless Community Network (WCN). WCN have emerged in recent years organized and deployed by the cooperation of its own customers.
Llorenc Cerda-Alabern +1 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Facile Characterization of Topology of DNA Catenanes [PDF]
Biophysical Journal, 2020 During the preparation of single-stranded DNA catenanes, topological isomers of different linking numbers (Lk) are intrinsically produced, and they must be separated from each other to construct sophisticated nanostructures accurately. In many previous studies, however, mixtures of these isomers were directly employed to construct nanostructures ...
Lin, Li +6 more
openaire +2 more sources