Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk +13 more
wiley +1 more source
S‐Adenosyl‐d‐Methionine as a Non‐Physiological Substrate for a Wide Range of SAM‐Dependent Enzymes
From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Philipp Germer +17 more
wiley +1 more source
Abstract Long‐term SO2 emission rate time series are critical for deciphering the subsurface processes regulating open‐vent volcanoes, yet extracting cyclical drivers from continuous degassing records remains challenging. We analyze a 14‐year (2006–2020) SO2 emission rate data set from Whakaari/White Island, New Zealand, identifying five chronological ...
A. Mazot +5 more
wiley +1 more source
PEMAHAMAN TEOLOGIS TENTANG KEHIDUPAN DOA DAN MENARA DOA
The life of prayer is a responsibility to set aside time to pray, to be disciplined in building a relationship with God, to have self-submission and reverence toward God, and to make prayer a necessity. Meanwhile, a prayer tower is an activity of prayer, praise, and worship that has taken place and is currently ongoing.
openaire +1 more source
Abstract Nitrogen dioxide (NO2) is a key indicator of unhealthy air, yet its sub‐daily spatiotemporal variability has not been widely characterized across large spatial scales in North America. Tropospheric Emissions: Monitoring of Pollution (TEMPO), a geostationary hyperspectral UV‐Vis instrument, offers up to 12 hourly observations per location ...
Daniel L. Goldberg +7 more
wiley +1 more source
Jaw tone dynamics across varying depths of anesthesia in a swine model
ObjectiveTo determine if jaw tone measured objectively can predict a non-surgical depth of anesthesia (DoA) or reliably distinguish between surgical and non-surgical DoA.Study designProspective, randomized, crossover experimental trial.AnimalsNine, five ...
McKenna Andelin +3 more
doaj +1 more source
Joint Estimation of Coherent Signal DOA and Polarization Parameters Based on Improved BSBL. [PDF]
Du Y, Peng J, Hu D, Wang J, Zeng H.
europepmc +1 more source
Depth of anesthesia monitoring: Current evidence, clinical impact, and future directions. [PDF]
Yu H, Gao B, Li Y.
europepmc +1 more source
Deacetyl Ophiopojaponin A ameliorates Asthma by Inhibiting L-Type Calcium Channel Cav2.3 to Reduce Calcium Load in Airway Epithelial Cells. [PDF]
Li H +9 more
europepmc +1 more source
Hybrid Robust Beamforming Optimization for LEO Satellite Communications Under DOA Estimation Errors in Spectrum Sharing Scenarios. [PDF]
Wang Y, Xie X, Jia J.
europepmc +1 more source

