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Direct oral anticoagulants (DOACs): From the laboratory point of view [PDF]

Acta Pharmaceutica, 2022
Direct oral anticoagulants (DOACs) represent a new generation of drugs that have been increasingly used in the prevention and treatment of thromboembolic states.
Margetić Sandra, Goreta Sandra Šupraha, Ćelap Ivana, Razum Marija   +3 more
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Prescribing and Safety of Direct-Acting Oral Anticoagulants Compared to Warfarin in Patients with Atrial Fibrillation on Chronic Hemodialysis

Pharmacy, 2020
ESRD patients receiving hemodialysis (HD) were excluded from landmark trials evaluating direct-acting oral anticoagulants (DOACs) in atrial fibrillation (AF).
Estella Davis, Dallin Darais, Kevin Fuji, Paige Nekola, Khalid Bashir   +4 more
doaj   +1 more source

Therapeutic efficacy of direct oral anticoagulants and vitamin K antagonists for left ventricular thrombus: Systematic review and meta-analysis.

PLoS ONE, 2021
BackgroundAlthough several meta-analyses have compared efficacies of vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) for treatment of left ventricular thrombus (LVT), those meta-analyses included no single-arm studies.Methods and ...
Tetsuji Kitano, Yosuke Nabeshima, Masaharu Kataoka, Masaaki Takeuchi   +3 more
doaj   +1 more source

Cancer-associated thromboembolism: could direct-acting oral anticoagulants be a promising therapeutic option? Literature review

Forum of Clinical Oncology, 2020
Cancer-associated thromboembolism (CAT) is usually managed with low-molecular-weight heparins (LMWHs) or vitamin K antagonists (VKAs). The recent data suggest that direct-acting oral anticoagulants (DOACs) might have a role in the management of CAT both ...
Savvari Paraskevi
doaj   +1 more source

Risk Profiles of New Users of Oral Anticoagulants Between 2011 and 2019 in Germany

Clinical Epidemiology, 2023
Annemarie Voss,1 Bianca Kollhorst,2 Katharina Platzbecker,1 Ute Amann,1 Ulrike Haug1,3 1Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany; 2Department of Biometry and Data Management ...
Voss A, Kollhorst B, Platzbecker K, Amann U, Haug U   +4 more
doaj  

Efficacy and safety of new direct oral anticoagulants in chronic kidney disease: AHA 2019 updated guidelines and review of the literature

Polish Journal of Thoracic and Cardiovascular Surgery, 2020
Direct oral anticoagulants (DOACs) are the drug of choice for the treatment of atrial fibrillation-associated systemic embolism and reducing the risk of strokes in chronic kidney disease (CKD) patients.
Hubert Stępak, Zbigniew Krasiński, Andrzej Jawień, Navid Ahmadi, Adam Lipowski, Michał Stanisic   +5 more
doaj   +1 more source

Clinical Use of Direct Oral Anticoagulants and Reversal: Consideration for Vascular Surgeons

Journal of Vascular Diseases, 2023
Since their first approval in 2010, direct oral anticoagulants (DOACs) have become attractive for anticoagulant treatment. DOACs are indicated for the prevention and treatment of several cardiovascular conditions and have now emerged as leading ...
Alan Houben, Vincent Bonhomme, Marc Senard   +2 more
doaj   +1 more source

Risk of postpolypectomy bleeding in patients taking direct oral anticoagulants or clopidogrel

Scientific Reports, 2021
The usage of direct oral anticoagulants (DOACs) to prevent and treat thromboembolic events is gradually increasing. We aimed to evaluate the outcomes of patients taking DOACs after polypectomy.
Gwang-Un Kim, Sinwon Lee, Jaewon Choe, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang   +9 more
doaj   +1 more source

Distinct pleiotropic effects of direct oral anticoagulants on cultured endothelial cells: a comprehensive review

Frontiers in Pharmacology, 2023
Direct Oral Anticoagulants (DOACs) have simplified the treatment of thromboembolic disease. In addition to their established anticoagulant effects, there are indications from clinical and preclinical studies that DOACs exhibit also non-anticoagulant ...
Natalia Atzemian, Natalia Atzemian, Dimitra Kareli, Dimitra Kareli, Georgia Ragia, Georgia Ragia, Vangelis G. Manolopoulos, Vangelis G. Manolopoulos, Vangelis G. Manolopoulos   +8 more
doaj   +1 more source

Patient Perspectives on Factors Affecting Direct Oral Anticoagulant Use for Stroke Prevention in Atrial Fibrillation

Patient Preference and Adherence, 2021
Kristina Medlinskiene,1,2 Susan Richardson,3 Beth Fylan,1,4,5 Katherine Stirling,2 Marcus Rattray,1,4 Duncan Petty1 1Medicine Optimisation Research Group, School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK; 2Medicine Management
Medlinskiene K, Richardson S, Fylan B, Stirling K, Rattray M, Petty D   +5 more
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