Results 11 to 20 of about 450,414 (196)

One-Pot Morita-Baylis-Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ-Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation. [PDF]

ChemSusChem
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Ramos-Martín M, Del Río I, García-Álvarez J, Presa Soto A.   +3 more
europepmc   +2 more sources

Clinical characterization of probable Dementia with Lewy Bodies based on the initial clinical presentation in a Latin American Low‐ and Middle‐ Income Country [PDF]

Alzheimers Dement
Abstract Background Dementia with Lewy Bodies (DLB) is a specific type of dementia associated with the accumulation of alpha‐synuclein protein in the brain. The disease often presents heterogeneously in its early stages, and little is known about how this variability affects its progression.
Custodio N, Malaga M, Bustamante‐Paytan D, Huilca J, Aguero K, Verastegui G, Bartolo P, Bendezu D, Yauri Z, Montesinos R.   +9 more
europepmc   +2 more sources

Clinical, Neuropsychological, and Neuroimaging Features of Peruvian Patients with Primary Progressive Aphasia [PDF]

Alzheimers Dement
Abstract Background Primary progressive aphasias (PPA) are a group of neurodegenerative syndromes primarily characterized by the progressive loss of language. Despite established diagnostic criteria, identification can be challenging, especially in regions with limited resources and few studies, such as Latin America.
Bustamante‐Paytan D, Huilca J, Brown G, Albujar‐Pereira M, Aguero K, Verastegui G, Yauri Z, Bartolo P, Bendezu D, Lipa‐Pari K, Montesinos R, Custodio N.   +11 more
europepmc   +2 more sources

Assessing the Overlap in Diagnostic Criteria for Primary Progressive Aphasia in a Latin American Population [PDF]

Alzheimers Dement
Abstract Background Primary progressive aphasias (PPA) are characterized by a progressive deterioration of language. Despite the establishment of international criteria in 2011 defining three variants (semantic, nonfluent, and logopenic), these variants can present overlapping symptoms, making their identification and differentiation challenging.
Bustamante‐Paytan D, Huilca J, Brown G, Albujar‐Pereira M, Aguero K, Verastegui G, Yauri Z, Bartolo P, Bendezu D, Lipa‐Pari K, Montesinos R, Custodio N.   +11 more
europepmc   +2 more sources

Relationship between genetic risk and p‐tau concentration on cognitive performance in a multiethnic population from Peru [PDF]

Alzheimers Dement
Abstract Background The presence of APOE 4 is considered the main genetic risk factor for the development of dementia. Additionally, plasma p‐tau has been shown to be an important biomarker associated with Alzheimer's disease. However, these factors have been understudied in Latin American ethnic minorities, such as the Quechuas and Aymaras.
Rivera‐Fernandez C, Custodio N, Montesinos R, Muñoz‐Najar A, Reyes‐Dumeyer D, Tosto G, Soto‐Añari M.   +6 more
europepmc   +2 more sources

Clinical Validation and Standardization of the Brain Health Assessment in the Tablet‐Based Cognitive Assessment Tool (BHA‐TabCAT) in Peruvian Older Adults [PDF]

Alzheimers Dement
Abstract Background Detecting cognitive decline presents a significant challenge for researchers and clinicians, particularly in older adults with low educational levels or different sociocultural characteristics. Additionally, traditional normative data may under‐ or overestimate preliminary diagnoses in these populations, due its non‐use of measures ...
Muñoz‐Najar A, Montemurro M, del Carmen Tejada M, Rivera‐Fernandez C, Sanchez‐Fernandez M, Custodio N, Lanata S, Soto‐Añari M.   +7 more
europepmc   +2 more sources

Establishment of a Community Advisory Board in Lima, based on the adaptation of the Patient Advisor Toolkit to enhance recruitment in dementia research [PDF]

Alzheimers Dement
Abstract Background Community Advisory Boards (CABs) are formal groups of community members who collaborate with research teams. The establishment of CABs have been shown to be an effective strategy for enhancing community engagement in research. This study aims to illustrate the process of establishing a Community Advisory Board in Lima, Peru, based ...
Custodio B, Montesinos R, Huilca J, Bustamante‐Paytan D, Agüero‐Flores K, Verastegui G, Malaga M, Custodio N.   +7 more
europepmc   +2 more sources

Educational Disparities and Lower Cognitive Performance on MMSE and RUDAS Despite Neuroanatomical and Functional Preservation in Aging: Insights from Peru [PDF]

Alzheimers Dement
Abstract Background Cognitive assessment of older adults who are either illiterate or with low levels of education is particularly challenging because several battery tasks require a certain educational background, despite a large portion of the world having not completed primary school.
Brown G, Bustamante‐Paytan D, Albujar‐Pereira M, Huilca J, Agüero K, Verastegui G, Yauri Z, Bartolo P, Bendezu D, Lipa‐Pari K, Montesinos R, Ibanez A, Custodio N.   +12 more
europepmc   +2 more sources

Divergent Functional Capacity in Alzheimer's Disease and Frontotemporal Dementia: Insights from the Peruvian Adaptation of the Amsterdam Instrumental Activities of Daily Living Questionnaire [PDF]

Alzheimers Dement
Abstract Background Instrumental activities of daily living (IADL) involve activities with higher cognitive demands, such as meal preparation, shopping, home maintenance, and financial management. IADL disturbances often emerge in early disease stages, affected by cognitive deficits regardless of dementia diagnosis.
Brown G, Bustamante‐Paytan D, Albujar‐Pereira M, Huilca J, Aguero K, Verastegui G, Yauri Z, Bartolo P, Bendezu D, Lipa‐Pari K, Montesinos R, Custodio N.   +11 more
europepmc   +2 more sources

Association between brain structure imaging and health factors in a low education cohort [PDF]

Alzheimers Dement
Abstract Background Dementia is rising globally, with a significant impact in Latin America. Low education has been associated with reduced cognitive reserve and structural brain changes, increasing vulnerability to neurodegeneration. However, the factors influencing these brain alterations remain an emerging area of research.
Brown G, Bustamante‐Paytan D, Huilca J, Albujar‐Pereira M, Aguero K, Verastegui G, Yauri Z, Bartolo P, Bendezu D, Lipa‐Pari K, Montesinos R, Custodio N.   +11 more
europepmc   +2 more sources