Results 121 to 130 of about 27,276 (262)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Extending the Containers of the Data Processing Platform on the Edge of the Network

Acta Electrotechnica et Informatica
This article describes the expansion of an existing data processing platform. This work aimed to analyze the current state of the platform, identify possible shortcomings, and propose new containers.
Urblík L’ubomír, Čorbová Sofia, Kajáti Erik, Papcun Peter   +3 more
doaj   +1 more source

bgruening/docker-galaxy-exome-seq: 19.01 release

, 2019
Galaxy Docker Image for Exome ...
Bérénice Batut, Björn Grüning, Anthony Bretaudeau   +2 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Editorial

Österreichische Zeitschrift für Geschichtswissenschaften, 1995
Ulrike Döcker, Gabriella Hauch
doaj   +1 more source

Analysis of docker container Implementation in SIEM infrastructure

Journal of Applied Informatics and Computing
It is known that configuring system information and event management (SIEM) infrastructure using conventional virtualization still provides essential functions.
Noper Ardi, Ahmadi Irmansyah Lubis, Ikhwan Ash Shafa Arrafi   +2 more
doaj   +1 more source

evbauer/MESA-Docker: MESA 11554

, 2018
<p>Default container runs MESA 11554. This release version fixes a memory leak and manages memory usage more aggressively. This may be especially useful for MESA-Docker users when containers have a limited amount of RAM allocated to them, so ...
Robert Farmer, Evan B. Bauer
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

hms-dbmi/higlass-docker: v0.4.17

, 2018
<p>Builds a docker container wrapping higlass-server and higlass-client in nginx</p ...
mccalluc, Peter Kerpedjiev, Scott Ouellette   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source