Results 191 to 200 of about 58,341 (324)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

MGDB: A Novel Bioinformatics Quality Control Tool for Clinical Next-Generation Sequencing. [PDF]

Cancer Inform
Gayap HT, Robichaud PP, Crapoulet N, Allain EP.   +3 more
europepmc   +1 more source

Seguretat en Docker: Anàlisi i protecció de vulnerabilitats

, 2020
Nin Ramírez, Oriol
openalex   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Orthogonal cation and anion template-directed synthesis of a heteroditopic [3]catenane for ion-pair recognition. [PDF]

Chem Sci
Tay HM, Docker A, Martínez-Martínez AJ, Beer PD.   +3 more
europepmc   +1 more source

Uma análise de segurança no uso de contêineres Docker em máquinas virtuais

, 2019
Kerolayne Oliveira, Charles C. Miers
openalex   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Protocol for predicting single- and multiple-dose-dependent gene expression using deep generative learning. [PDF]

STAR Protoc
Bowman DE, Panda V, Marri D, Kana O, Bhattacharya S.   +4 more
europepmc   +1 more source

LEO SC26 Artifact Evaluation — Pre-built Docker Images (v0.1.14)

Yuning Xia, John Mellor-Crummey
openalex   +1 more source

Implementation of informatics for integrating biology and the bedside (i2b2) platform as Docker containers [PDF]

, 2018
Kavishwar B. Wagholikar, Pralav Dessai, Javier Martínez‐Sanz, Michael Mendis, Douglas S. Bell, Shawn N. Murphy   +5 more
openalex   +1 more source